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    CG43658 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32729, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG43658provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263706
    Locus tag
    Dmel_CG43658
    See related
    AllianceGenome:FB:FBgn0263706
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12432; CG8557; Dmel\CG43658
    Old locus tag
    Dmel_CG12432; Dmel_CG8557
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Involved in imaginal disc-derived leg morphogenesis. Predicted to be active in cytoplasm. Is expressed in adepithelial cell of leg disc and adult head. Human ortholog(s) of this gene implicated in ovarian endometrial cancer and ovarian serous carcinoma. Orthologous to several human genes including ARHGEF10 (Rho guanine nucleotide exchange factor 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG43658 in Genome Data Viewer
    Location:
    16A5-16B4; 1-57 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17456169..17561180, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17350202..17455213, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene presidents-cup Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44692 Neighboring gene antisense RNA:CR44124 Neighboring gene pickpocket 23 Neighboring gene Ankle2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Larval density can be used to predict genetic modifiers of glucagon signaling in Drosophila melanogaster. Nicol A, et al. PLoS One, 2024. PMID 39196987, Free PMC Article
    2. Change in RhoGAP and RhoGEF availability drives transitions in cortical patterning and excitability in Drosophila. Jackson JA, et al. Curr Biol, 2024 May 20. PMID 38688282,
    3. Rare recombination events generate sequence diversity among balancer chromosomes in Drosophila melanogaster. Miller DE, et al. Proc Natl Acad Sci U S A, 2016 Mar 8. PMID 26903656, Free PMC Article
    4. Systematic expression and loss-of-function analysis defines spatially restricted requirements for Drosophila RhoGEFs and RhoGAPs in leg morphogenesis. Greenberg L, et al. Mech Dev, 2011 Jan-Feb. PMID 20851182, Free PMC Article
    5. Drosophila Charcot-Marie-Tooth Disease Models. Yamaguchi M, et al. Adv Exp Med Biol, 2018. PMID 29951817

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c17554681-17554504 mobile_element_type = transposon:INE-1{}4236

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in imaginal disc-derived leg morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Rho protein signal transduction IC
    Inferred by Curator
    more info
    		  
    involved_in positive regulation of stress fiber assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG43658-PA
    CG43658-PB
    CG43658-PC
    CG43658-PD
    CG43658-PE
    CG43658-PF
    CG43658-PG
    CG43658-PH

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      17456169..17561180 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272715.2 → NP_001259644.1  uncharacterized protein Dmel_CG43658, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259644.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86B45, Q8T9F7, Q9VX48
      Conserved Domains (1) summary
      pfam00621
      Location:179 → 348
      RhoGEF; RhoGEF domain

    2. NM_001272714.2 → NP_001259643.1  uncharacterized protein Dmel_CG43658, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259643.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHU0
      Conserved Domains (1) summary
      pfam00621
      Location:984 → 1153
      RhoGEF; RhoGEF domain

    3. NM_001169309.2 → NP_001162780.2  uncharacterized protein Dmel_CG43658, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162780.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JJN5
      Conserved Domains (1) summary
      pfam00621
      Location:457 → 626
      RhoGEF; RhoGEF domain

    4. NM_176751.5 → NP_788924.2  uncharacterized protein Dmel_CG43658, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788924.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86B45, Q8T9F7, Q9VX48
      Conserved Domains (1) summary
      pfam00621
      Location:179 → 348
      RhoGEF; RhoGEF domain

    5. NM_001298444.1 → NP_001285373.1  uncharacterized protein Dmel_CG43658, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285373.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEZ9
      Conserved Domains (1) summary
      pfam00621
      Location:179 → 348
      RhoGEF; RhoGEF domain

    6. NM_132990.3 → NP_573218.1  uncharacterized protein Dmel_CG43658, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573218.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86B45, Q8T9F7, Q9VX48
      Related
      FBpp0302019
      Conserved Domains (1) summary
      pfam00621
      Location:179 → 348
      RhoGEF; RhoGEF domain

    7. NM_001272716.1 → NP_001259645.1  uncharacterized protein Dmel_CG43658, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259645.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEZ9
      Conserved Domains (1) summary
      pfam00621
      Location:179 → 348
      RhoGEF; RhoGEF domain

    8. NM_001298445.1 → NP_001285374.1  uncharacterized protein Dmel_CG43658, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285374.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86B45, Q8T9F7, Q9VX48
      Conserved Domains (1) summary
      pfam00621
      Location:179 → 348
      RhoGEF; RhoGEF domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JJN5 E1JJN5
    M9PEZ9 M9PEZ9
    M9PHU0 M9PHU0
    Q9VX48 Q9VX48

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