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    Nup153 Nucleoporin 153kD [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32630, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nup153provided by FlyBase
    Official Full Name
    Nucleoporin 153kDprovided by FlyBase
    Primary source
    FLYBASE:FBgn0061200
    Locus tag
    Dmel_CG4453
    See related
    AllianceGenome:FB:FBgn0061200
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4453; Dmel\CG4453; dmNup153; dNup153; Nup 153; nup153; NUP153
    Summary
    Enables chromatin DNA binding activity. A structural constituent of nuclear pore. Involved in NLS-bearing protein import into nucleus; nuclear pore organization; and regulation of gene expression. Located in euchromatin; nuclear envelope; and nuclear periphery. Part of nuclear pore central transport channel. Is expressed in cyst progenitor cell; male germline stem cell; and spermatozoon. Orthologous to human NUP153 (nucleoporin 153). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nup153 in Genome Data Viewer
    Location:
    14F2-14F2; 1-54 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16599241..16610459)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16493274..16504492)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Structural maintenance of chromosomes 3 Neighboring gene Ubiquitin conjugating enzyme 7 Neighboring gene uncharacterized protein Neighboring gene mir-4965 stem loop Neighboring gene stable intronic sequence RNA 2 Neighboring gene mushroom bodies tiny Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNA association defines a functionally conserved domain in the nuclear pore protein Nup153. Dimaano C, et al. J Biol Chem, 2001 Nov 30. PMID 11567018
    2. Nup153 is not required for anchoring heterochromatic DSBs to the nuclear periphery. Ryu T, et al. MicroPubl Biol, 2024. PMID 38737725, Free PMC Article
    3. Molecular Evolution of Drosophila Germline Stem Cell and Neural Stem Cell Regulating Genes. Choi JY, et al. Genome Biol Evol, 2015 Oct 27. PMID 26507797, Free PMC Article
    4. A novel method to detect proteins evolving at correlated rates: identifying new functional relationships between coevolving proteins. Clark NL, et al. Mol Biol Evol, 2010 May. PMID 20044587, Free PMC Article
    5. Nuclear pore proteins nup153 and megator define transcriptionally active regions in the Drosophila genome. Vaquerizas JM, et al. PLoS Genet, 2010 Feb 12. PMID 20174442, Free PMC Article

    See all (80) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nup153 and Megator (Mtor) bind to 25% of the genome in continuous domains extending 10 kb to 500 kb.
      Title: Nuclear pore proteins nup153 and megator define transcriptionally active regions in the Drosophila genome.
    2. The FG repeats of Nup153 are necessary for its function in transport, whereas the remainder of the protein maintains pore integrity.
      Title: Distinct functions of the Drosophila Nup153 and Nup214 FG domains in nuclear protein transport.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of nuclear pore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in RNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear pore organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sex-chromosome dosage compensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in euchromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore central transport channel IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nucleoporin 153kD
    Names
    CG4453-PA
    CG4453-PC
    CG4453-PD
    Nup153-PA
    Nup153-PC
    Nup153-PD
    nucleoporin 153

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16599241..16610459
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144734.2 → NP_001138206.1  nucleoporin 153kD, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138206.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q1LZ48, Q9VXE6
      Conserved Domains (4) summary
      smart00547
      Location:1239 → 1261
      ZnF_RBZ; Zinc finger domain
      sd00025
      Location:864 → 883
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:1009 → 1038
      zf-RanBP; Zn-finger in Ran binding protein and others
      pfam08604
      Location:458 → 910
      Nup153; Nucleoporin Nup153-like

    2. NM_001103532.3 → NP_001097002.1  nucleoporin 153kD, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097002.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JV18
      Conserved Domains (4) summary
      smart00547
      Location:1239 → 1261
      ZnF_RBZ; Zinc finger domain
      sd00025
      Location:864 → 883
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:1009 → 1038
      zf-RanBP; Zn-finger in Ran binding protein and others
      pfam08604
      Location:458 → 910
      Nup153; Nucleoporin Nup153-like

    3. NM_132908.5 → NP_573136.3  nucleoporin 153kD, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573136.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q1LZ48, Q9VXE6
      Conserved Domains (4) summary
      smart00547
      Location:1239 → 1261
      ZnF_RBZ; Zinc finger domain
      sd00025
      Location:864 → 883
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:1009 → 1038
      zf-RanBP; Zn-finger in Ran binding protein and others
      pfam08604
      Location:458 → 910
      Nup153; Nucleoporin Nup153-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1YKA1 A1YKA1
    A1YKA3 A1YKA3
    A1YKA5 A1YKA5
    A1YKA7 A1YKA7
    A1YKA8 A1YKA8
    A1YKB1 A1YKB1
    A8JV18 A8JV18
    Q95SX4 Q95SX4
    Q960L2 Q960L2
    Q9VXE6.4 Q9VXE6

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