CkIalpha Casein kinase Ialpha [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CkIalphaprovided by FlyBase
Official Full Name: Casein kinase Ialphaprovided by FlyBase
Primary source: FLYBASE:FBgn0015024
Locus tag: Dmel_CG2028
See related: AllianceGenome:FB:FBgn0015024
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO03040301.93; anon-WO03040301.95; CG2028; CK I; CK1; ck1a; Ck1a; CK1a; ck1alpha; Ck1alpha; CK1alpha; ckI; CKI; CkI alpha; CKI alpha; CkIa; CKIa; ckIalpha; CKIalpha; dmCK1; dmckI; Dmel\CG2028; l(1)G0492; PKA-C
Summary: Enables protein serine/threonine kinase activity. Involved in several processes, including positive regulation of proteasomal ubiquitin-dependent protein catabolic process; regulation of signal transduction; and wound healing, spreading of epidermal cells. Located in cytoplasm and nucleus. Is expressed in adult head; organism; and spermatozoon. Orthologous to several human genes including CSNK1A1 (casein kinase 1 alpha 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 11B7-11B8; 1-39 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (12653626..12657834)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (12547659..12551867)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CHMP2B regulates TDP-43 phosphorylation and cytotoxicity independent of autophagy via CK1.
Title: CHMP2B regulates TDP-43 phosphorylation and cytotoxicity independent of autophagy via CK1.
Here, the authors show that the Casein Kinase 1 (CKI) family is required for Expanded phosphorylation. CKI expression promotes Expanded phosphorylation and interaction with Slimb/beta-TrCP.
Title: Casein kinase 1 family proteins promote Slimb-dependent Expanded degradation.
Ck1alpha interacts with DOUBLETIME to achieve the overall function of speeding up PERIOD metabolism and to ensure proper time-keeping.
Title: CK1α Collaborates with DOUBLETIME to Regulate PERIOD Function in the Drosophila Circadian Clock.
glucose regulatory role
Title: Drosophila glucome screening identifies Ck1alpha as a regulator of mammalian glucose metabolism.
we identify Casein Kinase I alpha (CK1alpha) as an additional negative-regulator of Cap-H2. CK1a-depletion stabilizes Cap-H2 protein and results in an accumulation of Cap-H2 on chromosomes.
Title: Drosophila casein kinase I alpha regulates homolog pairing and genome organization by modulating condensin II subunit Cap-H2 levels.
Expected genes in the Scar-Arp2/3 actin nucleation pathway were identified as well as casein kinase I, which had a similar morphological RNAi signature.
Title: A whole genome RNAi screen of Drosophila S2 cell spreading performed using automated computational image analysis.
Mutation of ck1alpha or -epsilon or sgg/gsk3beta in wing imaginal discs results in the accumulation of dMyc protein, suggesting a physiological role for these kinases in vivo.
Title: Identification of domains responsible for ubiquitin-dependent degradation of dMyc by glycogen synthase kinase 3beta and casein kinase 1 kinases.
Several CKI isoforms including CKIalpha and Gish/CKIgamma can phosphorylate the Wg coreceptor Arrow (Arr), which may account, at least in part, for their positive roles in the Wg pathway.
Title: Regulation of wingless signaling by the CKI family in Drosophila limb development.
CKI(Casein kinase I) functions as a negative regulator of Arm protein, by phosphorylating it on Ser and Thr residues in the N-terminus and targeting it for degradation.
Title: Casein kinase I phosphorylates the Armadillo protein and induces its degradation in Drosophila.
2 proteins reported to function in Wingless(Wg) signaling identified as Hh pathway components: Dally-like protein required for Hh signal reception, and casein kinase 1alpha, a candidate tumor suppressor that regulates activities of both Hh and Wg pathways
Title: Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair	IDA Inferred from Direct Assay more info	PubMed
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of canonical Wnt signaling pathway	IC Inferred by Curator more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of proteasomal protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in wound healing, spreading of epidermal cells	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of beta-catenin destruction complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: casein kinase ialpha

Names: CG2028-PA; CG2028-PB; CG2028-PD; CG2028-PE; CG2028-PF; CG2028-PG; CkIalpha-PA; CkIalpha-PB; CkIalpha-PD; CkIalpha-PE; CkIalpha-PF; CkIalpha-PG; caesin kinase I alpha; casein kinase 1; casein kinase 1a; casein kinase 1alpha; casein kinase I; casein kinase-1

NP_001162737.1

EC 2.7.11.1

NP_001285163.1

EC 2.7.11.1

NP_001285164.1

EC 2.7.11.1

NP_511140.1

EC 2.7.11.1

NP_727631.1

EC 2.7.11.1

NP_727632.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

12653626..12657834

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001298234.1 → NP_001285163.1 casein kinase ialpha, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285163.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V4D3, P54367, Q0KHT2, Q9VYK2

UniProtKB/TrEMBL

E1JJI5

Conserved Domains (1) summary

cl21453
Location:19 → 284

PKc_like; Protein Kinases, catalytic domain
NM_078585.6 → NP_511140.1 casein kinase ialpha, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_511140.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V4D3, P54367, Q0KHT2, Q9VYK2

UniProtKB/TrEMBL

E1JJI5

Related

FBpp0073513

Conserved Domains (1) summary

cl21453
Location:19 → 284

PKc_like; Protein Kinases, catalytic domain
NM_001169266.3 → NP_001162737.1 casein kinase ialpha, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162737.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V4D3, P54367, Q0KHT2, Q9VYK2

UniProtKB/TrEMBL

E1JJI5

Conserved Domains (1) summary

cl21453
Location:19 → 284

PKc_like; Protein Kinases, catalytic domain
NM_001298235.1 → NP_001285164.1 casein kinase ialpha, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285164.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V4D3, P54367, Q0KHT2, Q9VYK2

UniProtKB/TrEMBL

E1JJI5

Conserved Domains (1) summary

cl21453
Location:19 → 284

PKc_like; Protein Kinases, catalytic domain
NM_167332.3 → NP_727632.1 casein kinase ialpha, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727632.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V4D3, P54367, Q0KHT2, Q9VYK2

UniProtKB/TrEMBL

E1JJI5

Related

FBpp0311373

Conserved Domains (1) summary

cl21453
Location:19 → 284

PKc_like; Protein Kinases, catalytic domain
NM_167331.4 → NP_727631.1 casein kinase ialpha, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727631.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V4D3, P54367, Q0KHT2, Q9VYK2

UniProtKB/TrEMBL

E1JJI5

Related

FBpp0073515

Conserved Domains (1) summary

cl21453
Location:19 → 284

PKc_like; Protein Kinases, catalytic domain