Rab40 Rab40 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rab40provided by FlyBase
Official Full Name: Rab40provided by FlyBase
Primary source: FLYBASE:FBgn0030391
Locus tag: Dmel_CG1900
See related: AllianceGenome:FB:FBgn0030391
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 24641533; CG1900; Dmel\CG1900; DmRab40; Q8IR80; rab40
Summary: Enables GTPase activity. Involved in Golgi organization. Acts upstream of with a positive effect on lipophagy. Located in cytosol. Colocalizes with Golgi apparatus and lipid droplet. Is expressed in larval ventral nerve cord. Orthologous to several human genes including RAB40C (RAB40C, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 11A11-11A11; 1-38 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (12459796..12463112, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (12353829..12357145, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of lipid homeostasis by the TBC protein dTBC1D22 via modulation of the small GTPase Rab40 to facilitate lipophagy.
Title: Regulation of lipid homeostasis by the TBC protein dTBC1D22 via modulation of the small GTPase Rab40 to facilitate lipophagy.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Golgi organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Rab protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_positive_effect lipophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
colocalizes_with Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with lipid droplet	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in vesicle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Rab40

Names: CG1900-PA; CG1900-PB; CG1900-PC; Rab40-PA; Rab40-PB; Rab40-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

12459796..12463112 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_132572.3 → NP_572800.2 Rab40, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_572800.2

Status: REVIEWED

UniProtKB/TrEMBL

Q95RQ2, Q9VYM8

Related

FBpp0073501

Conserved Domains (3) summary

cd04121
Location:6 → 255

Rab40; Rab GTPase family 40 (Rab40) contains Rab40a, Rab40b and Rab40c

smart00175
Location:12 → 172

RAB; Rab subfamily of small GTPases

cl02533
Location:182 → 224

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
NM_167323.2 → NP_727611.1 Rab40, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727611.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IR80, Q95RQ2

Related

FBpp0073502

Conserved Domains (3) summary

smart00175
Location:12 → 182

RAB; Rab subfamily of small GTPases

cl02533
Location:192 → 234

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

cl21455
Location:6 → 265

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001298224.1 → NP_001285153.1 Rab40, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285153.1

Status: REVIEWED

UniProtKB/TrEMBL

Q95RQ2, Q9VYM8

Conserved Domains (3) summary

cd04121
Location:6 → 255

Rab40; Rab GTPase family 40 (Rab40) contains Rab40a, Rab40b and Rab40c

smart00175
Location:12 → 172

RAB; Rab subfamily of small GTPases

cl02533
Location:182 → 224

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...