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    ric8a ric8a [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31874, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ric8aprovided by FlyBase
    Official Full Name
    ric8aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028292
    Locus tag
    Dmel_CG15797
    See related
    AllianceGenome:FB:FBgn0028292
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15797; Dmel\CG15797; DmRic8; l(1)G0397; ric-8; Ric-8; RIC-8; ric-8a; Ric-8A; Ric8a
    Summary
    Enables G-protein alpha-subunit binding activity. Involved in several processes, including establishment of mitotic spindle localization; gastrulation involving germ band extension; and protein stabilization. Located in cytosol; type Ib terminal bouton; and type Is terminal bouton. Is expressed in organism. Orthologous to several human genes including RIC8A (RIC8 guanine nucleotide exchange factor A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ric8a in Genome Data Viewer
    Location:
    8D3-8D3; 1-27 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9256168..9259202)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9150201..9153235)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Downstream of raf1 Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila G-protein signalling: intricate roles for Ric-8? Matsuzaki F. Nat Cell Biol, 2005 Nov. PMID 16385732
    2. Neomorphic Gαo mutations gain interaction with Ric8 proteins in GNAO1 encephalopathies. Solis GP, et al. J Clin Invest, 2024 Jun 14. PMID 38874642, Free PMC Article
    3. Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome. Mansilla A, et al. Proc Natl Acad Sci U S A, 2017 Feb 7. PMID 28119500, Free PMC Article
    4. The guanine-exchange factor Ric8a binds to the Ca²⁺ sensor NCS-1 to regulate synapse number and neurotransmitter release. Romero-Pozuelo J, et al. J Cell Sci, 2014 Oct 1. PMID 25074811
    5. Heterotrimeric G protein signaling governs the cortical stability during apical constriction in Drosophila gastrulation. Kanesaki T, et al. Mech Dev, 2013 Feb. PMID 23085574

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neomorphic Galphao mutations gain interaction with Ric8 proteins in GNAO1 encephalopathies.
      Title: Neomorphic Gαo mutations gain interaction with Ric8 proteins in GNAO1 encephalopathies.
    2. the small molecule stabilizes a mobile C-terminal helix inside a hydrophobic crevice of NCS-1 to impede Ric8a interaction.
      Title: Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome.
    3. Data indicate that Ric-8 binds to Galpha12/13 subunit, Concertina (Cta) through an interface of conserved residues.
      Title: Drosophila Ric-8 interacts with the Gα12/13 subunit, Concertina, during activation of the Folded gastrulation pathway.
    4. New studies show that targeting of G-protein subunits to membrane requires Ric-8, pointing to possible novel roles for this protein in both receptor-dependent and independent pathways.
      Title: Drosophila G-protein signalling: intricate roles for Ric-8?
    5. Ric-8 homologue is required for asymmetric division of both NBs and pl cells.Ric-8 is necessary for membrane targeting of Galphai, Pins and Gbeta13F
      Title: Ric-8 controls Drosophila neural progenitor asymmetric division by regulating heterotrimeric G proteins.
    6. both receptor-dependent and receptor-independent G-protein functions are executed at the plasma membrane and require the Ric-8 protein.
      Title: Drosophila Ric-8 is essential for plasma-membrane localization of heterotrimeric G proteins.
    7. Ric-8, which belongs to a family of guanine nucleotide-exchange factors for Galphai, regulates cortical localization of the subunits Galphai and Gbeta13F.
      Title: Drosophila Ric-8 regulates Galphai cortical localization to promote Galphai-dependent planar orientation of the mitotic spindle during asymmetric cell division.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G-protein alpha-subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G-protein alpha-subunit binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in asymmetric cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of mitotic spindle localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment or maintenance of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gastrulation involving germ band extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuroblast division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neurotransmitter secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in type Ib terminal bouton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in type Is terminal bouton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ric8a
    Names
    CG15797-PA
    CG15797-PB
    ric8a-PA
    ric8a-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      9256168..9259202
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298119.1 → NP_001285048.1  ric8a, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285048.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W358
      UniProtKB/TrEMBL
      X2JEL4
      Conserved Domains (1) summary
      pfam10165
      Location:67 → 548
      Ric8; Guanine nucleotide exchange factor synembryn

    2. NM_132322.4 → NP_572550.2  ric8a, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572550.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W358
      UniProtKB/TrEMBL
      X2JEL4
      Related
      FBpp0071252
      Conserved Domains (1) summary
      pfam10165
      Location:67 → 548
      Ric8; Guanine nucleotide exchange factor synembryn
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W358.2 Q9W358
    X2JEL4 X2JEL4

    Gene LinkOut

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