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    UbcE2H Ubiquitin conjugating enzyme E2H [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31728, updated on 9-Dec-2024

    Summary

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    Official Symbol
    UbcE2Hprovided by FlyBase
    Official Full Name
    Ubiquitin conjugating enzyme E2Hprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029996
    Locus tag
    Dmel_CG2257
    See related
    AllianceGenome:FB:FBgn0029996
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2257; Dmel\CG2257; dUbc-E2H; Kdo; Ubc-2EH; Ubc-E2H; UBC-E2H; Ubc-E2Hs; UbcDE2H; ubcE2h
    Summary
    Predicted to enable ubiquitin conjugating enzyme activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Part of GID complex. Used to study viral infectious disease. Orthologous to human UBE2H (ubiquitin conjugating enzyme E2 H). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See UbcE2H in Genome Data Viewer
    Location:
    7D6-7D6; 1-22 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8087544..8094064, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7981577..7988097, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Lipid droplet subset dehydrogenase 1 Neighboring gene antisense RNA:CR45535 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Glutamate-cysteine ligase catalytic subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Combining experimental evolution with next-generation sequencing: a powerful tool to study adaptation from standing genetic variation. Schlötterer C, et al. Heredity (Edinb), 2015 May. PMID 25269380, Free PMC Article
    2. Readapting to DCV Infection without Wolbachia: Frequency Changes of Drosophila Antiviral Alleles Can Replace Endosymbiont Protection. Faria VG, et al. Genome Biol Evol, 2018 Jul 1. PMID 29947761, Free PMC Article
    3. Host adaptation to viruses relies on few genes with different cross-resistance properties. Martins NE, et al. Proc Natl Acad Sci U S A, 2014 Apr 22. PMID 24711428, Free PMC Article
    4. The E2 Marie Kondo and the CTLH E3 ligase clear deposited RNA binding proteins during the maternal-to-zygotic transition. Zavortink M, et al. Elife, 2020 Jun 23. PMID 32573431, Free PMC Article
    5. Identification of genes that modify ataxin-1-induced neurodegeneration. Fernandez-Funez P, et al. Nature, 2000 Nov 2. PMID 11081516

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of GID complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin conjugating enzyme E2H
    Names
    CG2257-PA
    CG2257-PB
    CG2257-PC
    Ubc-E2H
    UbcE2H-PA
    UbcE2H-PB
    UbcE2H-PC
    marie kondo
    NP_572438.1
    NP_727233.1
    NP_727234.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      8087544..8094064 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167145.2 → NP_727233.1  ubiquitin conjugating enzyme E2H, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727233.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2XYF2, Q7JW03
      Related
      FBpp0071067
      Conserved Domains (1) summary
      COG5078
      Location:1 → 149
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

    2. NM_132210.3 → NP_572438.1  ubiquitin conjugating enzyme E2H, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572438.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2XYF2, Q7JW03
      Related
      FBpp0071069
      Conserved Domains (1) summary
      COG5078
      Location:1 → 149
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

    3. NM_167146.2 → NP_727234.1  ubiquitin conjugating enzyme E2H, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727234.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2XYF2, Q7JW03
      Related
      FBpp0071068
      Conserved Domains (1) summary
      COG5078
      Location:1 → 149
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2XYF2 Q2XYF2
    Q7JW03 Q7JW03

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