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    dwg deformed wings [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31265, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dwgprovided by FlyBase
    Official Full Name
    deformed wingsprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000520
    Locus tag
    Dmel_CG2711
    See related
    AllianceGenome:FB:FBgn0000520
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2711; CG2714; Dmel\CG2711; Dwg; DWG; EG:95B7.6; l(1)3Be; l(1)zw5; Sbp; SBP; ves; zw-5; Zw-5; ZW-5; zw5; Zw5; ZW5
    Summary
    Enables chromatin insulator sequence binding activity. Predicted to be involved in regulation of DNA-templated transcription. Located in chromatin and nucleus. Is expressed in organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dwg in Genome Data Viewer
    Location:
    3B3-3B3; 1-1.5 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2727698..2730042)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2621731..2624075)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene female sterile (1) Young arrest Neighboring gene vilya Neighboring gene tiny tim 50 Neighboring gene uncharacterized protein Neighboring gene cramped

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Architectural proteins Pita, Zw5,and ZIPIC contain homodimerization domain and support specific long-range interactions in Drosophila. Zolotarev N, et al. Nucleic Acids Res, 2016 Sep 6. PMID 27137890, Free PMC Article
    2. Protein:protein interactions and the pairing of boundary elements in vivo. Blanton J, et al. Genes Dev, 2003 Mar 1. PMID 12629048, Free PMC Article
    3. [Translation elongation factor EF1α1 interacts with ZAD domains of transcription factors from Drosophila melanogaster]. Zolotarev NA, et al. Mol Biol (Mosk), 2016 Nov-Dec. PMID 28064318
    4. Deletions induced in the white and vermilion genes of Drosophila melanogaster by the antitumor drug cis-dichlorodiammineplatinum(II). Cizeau J, et al. Mutat Res, 1994 Nov 1. PMID 7526172
    5. Chromatin insulators and long-distance interactions in Drosophila. Kyrchanova O, et al. FEBS Lett, 2014 Jan 3. PMID 24211836

    See all (112) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin insulator sequence binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    deformed wings
    Names
    CG2711-PA
    deformed wing
    dwg-PA
    scs binding protein
    scs-binding protein
    vestigium
    zeste white 5
    zeste-white 5
    zeste-white5

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2727698..2730042
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057990.4 → NP_477338.3  deformed wings [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477338.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RB8, Q9W4V9
      Related
      FBpp0070465
      Conserved Domains (4) summary
      smart00868
      Location:14 → 91
      zf-AD; Zinc-finger associated domain (zf-AD)
      COG5048
      Location:387 → 523
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:363 → 383
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:403 → 426
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U9D0 Q9U9D0
    Q9W4V9 Q9W4V9

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