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    moody moody [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31168, updated on 9-Dec-2024

    Summary

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    Official Symbol
    moodyprovided by FlyBase
    Official Full Name
    moodyprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025631
    Locus tag
    Dmel_CG4322
    See related
    AllianceGenome:FB:FBgn0025631
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    1631; CG4322; Dmel\CG4322; EG:22E5.11; EP1631; Moody
    Summary
    Enables G protein-coupled receptor activity. Involved in several processes, including behavioral response to cocaine; behavioral response to ethanol; and nervous system development. Located in plasma membrane and pleated septate junction. Is expressed in several structures, including circulatory system primordium; embryonic/larval midgut primordium; ganglia; glial cell; and imaginal disc. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to several human genes including MTNR1A (melatonin receptor 1A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See moody in Genome Data Viewer
    Location:
    2C7-2C8; 1-0.5 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2044292..2050120, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1938325..1944153, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene alpha actinin Neighboring gene ultraspiracle Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44896 Neighboring gene Salt-inducible kinase 2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Oatp58Dc contributes to blood-brain barrier function by excluding organic anions from the Drosophila brain. Seabrooke S, et al. Am J Physiol Cell Physiol, 2013 Sep. PMID 23804204
    2. Dynamic analysis of the mesenchymal-epithelial transition of blood-brain barrier forming glia in Drosophila. Schwabe T, et al. Biol Open, 2017 Feb 15. PMID 28108476, Free PMC Article
    3. Investigation of Evolutionary History and Origin of the Tre1 Family Suggests a Role in Regulating Hemocytes Cells Infiltration of the Blood-Brain Barrier. Kubick N, et al. Insects, 2021 Sep 29. PMID 34680651, Free PMC Article
    4. TU-tagging: cell type-specific RNA isolation from intact complex tissues. Miller MR, et al. Nat Methods, 2009 Jun. PMID 19430475, Free PMC Article
    5. Drosophila glia take shape to sculpt the nervous system. Corty MM, et al. Curr Opin Neurobiol, 2023 Apr. PMID 36822142, Free PMC Article

    See all (113) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The cAMP effector PKA mediates Moody GPCR signaling in Drosophila blood-brain barrier formation and maturation.
      Title: The cAMP effector PKA mediates Moody GPCR signaling in Drosophila blood-brain barrier formation and maturation.
    2. RNAi-based screens uncover a potential new role for the orphan neuropeptide receptor Moody in Drosophila female germline stem cell maintenance.
      Title: RNAi-based screens uncover a potential new role for the orphan neuropeptide receptor Moody in Drosophila female germline stem cell maintenance.
    3. The results suggest a mechanism by which the Drosophila BBB is maintained by Moody/GPCR-dependent formation of ARSs, which is supported by myosin activation.
      Title: The Drosophila blood brain barrier is maintained by GPCR-dependent dynamic actin structures.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in axon ensheathment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in behavioral response to cocaine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in behavioral response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in behavioral response to nicotine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cortical actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of glial blood-brain barrier IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in septate junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ventral cord development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in pleated septate junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    moody
    Names
    CG4322-PA
    CG4322-PB
    CG4322-PC
    CG4322-PD
    CG4322-PE
    CG4322-PF
    moody receptor
    moody-PA
    moody-PB
    moody-PC
    moody-PD
    moody-PE
    moody-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2044292..2050120 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201607.2 → NP_001188536.1  moody, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188536.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MS14
      Conserved Domains (2) summary
      pfam00001
      Location:53 → 363
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:44 → 167
      7tm_4; Olfactory receptor

    2. NM_001201605.2 → NP_001188534.1  moody, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188534.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77270, Q8MRD0, Q9W534
      UniProtKB/TrEMBL
      M9PDK4
      Conserved Domains (2) summary
      pfam00001
      Location:53 → 363
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:44 → 167
      7tm_4; Olfactory receptor

    3. NM_001272241.2 → NP_001259170.1  moody, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259170.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77270, Q8MRD0, Q9W534
      UniProtKB/TrEMBL
      M9PDK4
      Conserved Domains (2) summary
      pfam00001
      Location:53 → 363
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:44 → 167
      7tm_4; Olfactory receptor

    4. NM_001201606.2 → NP_001188535.1  moody, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188535.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MS14
      Conserved Domains (2) summary
      pfam00001
      Location:53 → 363
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:44 → 167
      7tm_4; Olfactory receptor

    5. NM_130614.4 → NP_569970.2  moody, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569970.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77270, Q8MRD0, Q9W534
      UniProtKB/TrEMBL
      M9PDK4
      Related
      FBpp0070327
      Conserved Domains (2) summary
      pfam00001
      Location:53 → 363
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:44 → 167
      7tm_4; Olfactory receptor

    6. NM_001272242.2 → NP_001259171.1  moody, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259171.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77270, Q8MRD0, Q9W534
      UniProtKB/TrEMBL
      M9PDK4
      Conserved Domains (2) summary
      pfam00001
      Location:53 → 363
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:44 → 167
      7tm_4; Olfactory receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9MS14 M9MS14
    M9PDK4 M9PDK4
    Q9W534.2 Q9W534

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