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    Adar Adenosine deaminase acting on RNA [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31130, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adarprovided by FlyBase
    Official Full Name
    Adenosine deaminase acting on RNAprovided by FlyBase
    Primary source
    FLYBASE:FBgn0026086
    Locus tag
    Dmel_CG12598
    See related
    AllianceGenome:FB:FBgn0026086
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    adar; ADAR; ADAR1; adr; cg12598; CG12598; dadar; dAdar; dADAR; Dmel\CG12598; EG:BACN35H14.1; hypnos-2
    Summary
    Enables double-stranded RNA adenosine deaminase activity. Involved in several processes, including RNA modification; locomotor rhythm; and male courtship behavior. Located in nucleolus. Is expressed in several structures, including adult head; amnioproctodeal invagination; brain; ectoderm anlage; and embryonic/larval gut. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human ADARB1 (adenosine deaminase RNA specific B1) and ADARB2 (adenosine deaminase RNA specific B2 (inactive)). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Adar in Genome Data Viewer
    Location:
    2B9-2B9; 1-0.2 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1773725..1788065)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1667758..1682098)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Sarcoglycan delta Neighboring gene prage Neighboring gene mir-981 stem loop Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Solution structure of the N-terminal dsRBD of Drosophila ADAR and interaction studies with RNA. Barraud P, et al. Biochimie, 2012 Jul. PMID 22210494, Free PMC Article
    2. Identification of RNA-binding protein targets with HyperTRIBE. Rahman R, et al. Nat Protoc, 2018 Aug. PMID 30013039, Free PMC Article
    3. The landscape of miRNA editing in animals and its impact on miRNA biogenesis and targeting. Li L, et al. Genome Res, 2018 Jan. PMID 29233923, Free PMC Article
    4. Dynamic hyper-editing underlies temperature adaptation in Drosophila. Buchumenski I, et al. PLoS Genet, 2017 Jul. PMID 28746393, Free PMC Article
    5. Evolutionary analysis reveals regulatory and functional landscape of coding and non-coding RNA editing. Zhang R, et al. PLoS Genet, 2017 Feb. PMID 28166241, Free PMC Article

    See all (141) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Adar Regulates Drosophila melanogaster Spermatogenesis via Modulation of BMP Signaling.
      Title: Adar Regulates Drosophila melanogaster Spermatogenesis via Modulation of BMP Signaling.
    2. Comparative genomic analyses reveal evidence for adaptive A-to-I RNA editing in insect Adar gene.
      Title: Comparative genomic analyses reveal evidence for adaptive A-to-I RNA editing in insect Adar gene.
    3. Proteome-Wide Analysis of ADAR-Mediated Messenger RNA Editing during Fruit Fly Ontogeny.
      Title: Proteome-Wide Analysis of ADAR-Mediated Messenger RNA Editing during Fruit Fly Ontogeny.
    4. Zinc Finger RNA-Binding Protein Zn72D Regulates ADAR-Mediated RNA Editing in Neurons.
      Title: Zinc Finger RNA-Binding Protein Zn72D Regulates ADAR-Mediated RNA Editing in Neurons.
    5. Drosophila Adar, despite being the homolog of mammalian ADAR2, also has functions similar to mammalian ADAR1.
      Title: Adar RNA editing-dependent and -independent effects are required for brain and innate immune functions in Drosophila.
    6. our data shows that ADAR is essential for proper temperature adaptation, a key behavior trait that is essential for survival of flies in the wild. Moreover, our results suggest a more general role of ADAR in regulating RNA secondary structures in vivo
      Title: Dynamic hyper-editing underlies temperature adaptation in Drosophila.
    7. Deficiencies in the RNA-editing gene Adar increase sleep due to synaptic dysfunction in glutamatergic neurons.
      Title: ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity.
    8. The study demonstrates that neuronal excitability is linked to dADAR expression levels in individual neurons.
      Title: The ADAR RNA editing enzyme controls neuronal excitability in Drosophila melanogaster.
    9. loss of Adar increases quantal size, reduces the number of quanta of neurotransmitter released and perturbs the calcium dependence of synaptic release
      Title: Adar is essential for optimal presynaptic function.
    10. results demonstrate a novel role for dADAR protein in rnp-4f 5'-UTR alternative intron splicing regulation which is consistent with a previously proposed model.
      Title: An RNA electrophoretic mobility shift and mutational analysis of rnp-4f 5'-UTR intron splicing regulatory proteins in Drosophila reveals a novel new role for a dADAR protein isoform.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenosine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded RNA adenosine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded RNA adenosine deaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded RNA adenosine deaminase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA-specific adenosine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA modification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenosine to inosine editing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenosine to inosine editing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adenosine to inosine editing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in adult behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotor rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA modification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male courtship behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-transcriptional regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of circadian rhythm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    adenosine deaminase acting on RNA
    Names
    Adar-PA
    Adar-PB
    Adar-PC
    Adar-PD
    Adar-PE
    Adar-PF
    Adar-PH
    Adar-PI
    Adar-PJ
    Adar-PK
    Adar-PM
    Adar-PN
    Adar-PO
    Adar-PP
    Adar-PQ
    CG12598-PA
    CG12598-PB
    CG12598-PC
    CG12598-PD
    CG12598-PE
    CG12598-PF
    CG12598-PH
    CG12598-PI
    CG12598-PJ
    CG12598-PK
    CG12598-PM
    CG12598-PN
    CG12598-PO
    CG12598-PP
    CG12598-PQ
    adenosine deaminase acting on rna
    adenosine deaminases acting on RNA
    hypnos-2
    hypoxia, anoxia, sensitive 2
    NP_001033821.1
    NP_001245469.1
    NP_001245470.1
    NP_001245471.1
    NP_001245472.2
    NP_001245473.1
    NP_001245474.1
    NP_001245475.1
    NP_001245476.1
    NP_001245477.1
    NP_001284791.1
    NP_001284792.1
    NP_001368969.1
    NP_569940.2
    NP_726761.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1773725..1788065
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258548.2 → NP_001245477.1  adenosine deaminase acting on RNA, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245477.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O96834, Q8IRX2, Q8MSQ9, Q9BJ37, Q9NII1, Q9NII2, Q9W562
      UniProtKB/TrEMBL
      M9NGI0
      Conserved Domains (2) summary
      smart00358
      Location:34 → 96
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:236 → 607
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

    2. NM_001297862.1 → NP_001284791.1  adenosine deaminase acting on RNA, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284791.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O96834, Q8IRX2, Q8MSQ9, Q9BJ37, Q9NII1, Q9NII2, Q9W562
      UniProtKB/TrEMBL
      X2JHZ2
      Conserved Domains (3) summary
      smart00358
      Location:55 → 117
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:294 → 665
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      TIGR04238
      Location:57 → 242
      seadorna_dsRNA; seadornavirus double-stranded RNA-binding protein

    3. NM_166903.3 → NP_726761.2  adenosine deaminase acting on RNA, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726761.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O96834, Q8IRX2, Q8MSQ9, Q9BJ37, Q9NII1, Q9NII2, Q9W562
      Related
      FBpp0070287
      Conserved Domains (2) summary
      smart00358
      Location:51 → 113
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:253 → 624
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

    4. NM_001258547.2 → NP_001245476.1  adenosine deaminase acting on RNA, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245476.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O96834, Q8IRX2, Q8MSQ9, Q9BJ37, Q9NII1, Q9NII2, Q9W562
      UniProtKB/TrEMBL
      M9NEQ7
      Conserved Domains (2) summary
      smart00358
      Location:57 → 119
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:259 → 630
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

    5. NM_001038732.3 → NP_001033821.1  adenosine deaminase acting on RNA, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033821.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2PE36
      Conserved Domains (1) summary
      smart00358
      Location:55 → 117
      DSRM; Double-stranded RNA binding motif

    6. NM_130584.4 → NP_569940.2  adenosine deaminase acting on RNA, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569940.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O96834, Q8IRX2, Q8MSQ9, Q9BJ37, Q9NII1, Q9NII2, Q9W562
      UniProtKB/TrEMBL
      M9NFQ6
      Related
      FBpp0070286
      Conserved Domains (2) summary
      smart00358
      Location:55 → 117
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:257 → 628
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

    7. NM_001258545.2 → NP_001245474.1  adenosine deaminase acting on RNA, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245474.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O96834, Q8IRX2, Q8MSQ9, Q9BJ37, Q9NII1, Q9NII2, Q9W562
      UniProtKB/TrEMBL
      M9NFQ8
      Conserved Domains (3) summary
      smart00358
      Location:51 → 113
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:290 → 661
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      TIGR04238
      Location:53 → 238
      seadorna_dsRNA; seadornavirus double-stranded RNA-binding protein

    8. NM_001258546.2 → NP_001245475.1  adenosine deaminase acting on RNA, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245475.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6K8G4, C6SUW1
      Conserved Domains (2) summary
      smart00358
      Location:55 → 117
      DSRM; Double-stranded RNA binding motif
      cl02661
      Location:294 → 388
      A_deamin; Adenosine-deaminase (editase) domain

    9. NM_001258542.2 → NP_001245471.1  adenosine deaminase acting on RNA, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245471.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6K8G4, C6SUW1
      Conserved Domains (2) summary
      smart00358
      Location:55 → 117
      DSRM; Double-stranded RNA binding motif
      cl02661
      Location:294 → 388
      A_deamin; Adenosine-deaminase (editase) domain

    10. NM_001258544.2 → NP_001245473.1  adenosine deaminase acting on RNA, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245473.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NDJ0
      Conserved Domains (1) summary
      smart00358
      Location:57 → 119
      DSRM; Double-stranded RNA binding motif

    11. NM_001258543.2 → NP_001245472.2  adenosine deaminase acting on RNA, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245472.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6K8G3, C6SUW1, M9NGH5
      Conserved Domains (2) summary
      smart00358
      Location:55 → 117
      DSRM; Double-stranded RNA binding motif
      cl02661
      Location:257 → 351
      A_deamin; Adenosine-deaminase (editase) domain

    12. NM_001297863.1 → NP_001284792.1  adenosine deaminase acting on RNA, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284792.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6SUW1, X2JDG6
      Conserved Domains (2) summary
      smart00358
      Location:34 → 96
      DSRM; Double-stranded RNA binding motif
      cl02661
      Location:236 → 330
      A_deamin; Adenosine-deaminase (editase) domain

    13. NM_001258541.2 → NP_001245470.1  adenosine deaminase acting on RNA, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245470.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6SUW1, M9NE37
      Conserved Domains (2) summary
      smart00358
      Location:52 → 114
      DSRM; Double-stranded RNA binding motif
      cl02661
      Location:291 → 385
      A_deamin; Adenosine-deaminase (editase) domain

    14. NM_001258540.1 → NP_001245469.1  adenosine deaminase acting on RNA, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245469.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O96834, Q8IRX2, Q8MSQ9, Q9BJ37, Q9NII1, Q9NII2, Q9W562
      UniProtKB/TrEMBL
      M9NFQ6
      Conserved Domains (2) summary
      smart00358
      Location:55 → 117
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:257 → 628
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

    15. NM_001382020.1 → NP_001368969.1  adenosine deaminase acting on RNA, isoform Q [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O96834, Q8IRX2, Q8MSQ9, Q9BJ37, Q9NII1, Q9NII2, Q9W562
      UniProtKB/TrEMBL
      A0A6H2EFI6
      Conserved Domains (3) summary
      smart00552
      Location:306 → 677
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      cd19865
      Location:105 → 167
      DSRM_STRBP_RED-like_rpt1; first double-stranded RNA binding motif of STRBP, ILF3, RED1, RED2 and similar proteins
      cl00054
      Location:213 → 259
      DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A6H2EFI6 A0A6H2EFI6
    C6K8G3 C6K8G3
    C6K8G4 C6K8G4
    M9NDJ0 M9NDJ0
    M9NE37 M9NE37
    M9NEQ7 M9NEQ7
    M9NFQ6 M9NFQ6
    M9NFQ8 M9NFQ8
    M9NGI0 M9NGI0
    Q2PE36 Q2PE36
    Q9NII1.2 Q9NII1
    X2JDG6 X2JDG6
    X2JHZ2 X2JHZ2

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