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    dhrs7cb dehydrogenase/reductase (SDR family) member 7Cb [ Danio rerio (zebrafish) ]

    Gene ID: 553684, updated on 4-Jan-2025

    Summary

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    Official Symbol
    dhrs7cbprovided by ZNC
    Official Full Name
    dehydrogenase/reductase (SDR family) member 7Cbprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050522-226
    See related
    Ensembl:ENSDARG00000071877 AllianceGenome:ZFIN:ZDB-GENE-050522-226
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    dhrs7c; zgc:112176
    Summary
    Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in intracellular calcium ion homeostasis. Predicted to be located in extracellular region and membrane. Orthologous to human DHRS7C (dehydrogenase/reductase 7C). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See dhrs7cb in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (455552..463995, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (449611..458054, complement)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene gsg1-like 2b Neighboring gene heparan sulfate (glucosamine) 3-O-sulfotransferase 3-like Neighboring gene myosin phosphatase Rho interacting protein Neighboring gene si:dkey-94l16.4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Combined effects of polystyrene microplastics and natural organic matter on the accumulation and toxicity of copper in zebrafish. Qiao R, et al. Sci Total Environ, 2019 Sep 10. PMID 31117014
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112176

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on CH-OH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dehydrogenase/reductase (SDR family) member 7Cb
    Names
    dehydrogenase/reductase (SDR family) member 7C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001020657.1 → NP_001018493.1  dehydrogenase/reductase (SDR family) member 7Cb

      See identical proteins and their annotated locations for NP_001018493.1

      Status: PROVISIONAL

      Source sequence(s)
      BC095682
      UniProtKB/Swiss-Prot
      A8E5C5, Q502I7
      UniProtKB/TrEMBL
      A0A8M9Q8F6
      Related
      ENSDARP00000097447.4, ENSDART00000106669.5
      Conserved Domains (2) summary
      cd05332
      Location:35 → 309
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
      pfam00106
      Location:38 → 219
      adh_short; short chain dehydrogenase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      455552..463995 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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