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    LINC01315 long intergenic non-protein coding RNA 1315 [ Homo sapiens (human) ]

    Gene ID: 102723775, updated on 10-Dec-2024

    Summary

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    Official Symbol
    LINC01315provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 1315provided by HGNC
    Primary source
    HGNC:HGNC:50513
    See related
    Ensembl:ENSG00000229891 AllianceGenome:HGNC:50513
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C22orf32-1; lnc-C22orf32-1
    Expression
    Broad expression in thyroid (RPKM 6.7), skin (RPKM 2.3) and 15 other tissues See more
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    Genomic context

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    See LINC01315 in Genome Data Viewer
    Location:
    22q13.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (42364400..42369208, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (42845402..42850211, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (42760406..42765214, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene ccytochrome P450 family 2 subfamily D member 8, pseudogene Neighboring gene transcription factor 20 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:42610989-42611488 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr22:42613759-42614347 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19154 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19155 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13820 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13821 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13822 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13823 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:42670872-42671668 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr22:42671669-42672465 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19156 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:42678224-42679074 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:42679075-42679924 Neighboring gene opioid growth factor receptor pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:42690639-42691452 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:42693767-42694412 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:42695786-42696464 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:42696465-42697143 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:42697144-42697822 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:42706428-42707134 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:42709047-42709876 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:42710708-42711537 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:42714279-42715176 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:42716129-42716966 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:42721410-42722037 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:42734449-42735057 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:42735333-42735954 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:42735955-42736576 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:42747603-42748103 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19160 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:42759143-42759796 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:42761307-42762149 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:42763534-42764468 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19161 Neighboring gene Sharpr-MPRA regulatory region 6115 Neighboring gene uncharacterized LOC124905126 Neighboring gene Sharpr-MPRA regulatory region 1538 Neighboring gene NFAT activating protein with ITAM motif 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19162 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:42821196-42821779 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19163

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LINC01315 accelerates the growth and epithelial-mesenchymal transition of colorectal cancer cells via activating the Wnt/β-catenin signal. Liu Y, et al. Bioengineered, 2022 Apr. PMID 35322763, Free PMC Article
    2. LncRNA LINC01315 silencing modulates cancer stem cell properties and epithelial-to-mesenchymal transition in colorectal cancer via miR-484/DLK1 axis. Li Y, et al. Cell Cycle, 2022 Apr. PMID 35156543, Free PMC Article
    3. lncRNA C22orf32-1 contributes to the tumorigenesis of nasopharyngeal carcinoma. Nie GH, et al. Oncol Lett, 2017 Jun. PMID 28588717, Free PMC Article
    4. LINC01315 promotes the aggressive phenotypes of papillary thyroid cancer cells by sponging miR-497-5p. Ren J, et al. Kaohsiung J Med Sci, 2021 Jun. PMID 33611825
    5. LINC01315 silencing inhibits the aggressive phenotypes of colorectal carcinoma by sponging miR-205-3p. Liang R, et al. Biochem Biophys Res Commun, 2021 Jan 1. PMID 33162032

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LINC01315 accelerates the growth and epithelial-mesenchymal transition of colorectal cancer cells via activating the Wnt/beta-catenin signal.
      Title: LINC01315 accelerates the growth and epithelial-mesenchymal transition of colorectal cancer cells via activating the Wnt/β-catenin signal.
    2. lncRNA LINC01315 promotes malignancy of triple-negative breast cancer and predicts poor outcomes by modulating microRNA-876-5p/GRK5.
      Title: lncRNA LINC01315 promotes malignancy of triple-negative breast cancer and predicts poor outcomes by modulating microRNA-876-5p/GRK5.
    3. LncRNA LINC01315 silencing modulates cancer stem cell properties and epithelial-to-mesenchymal transition in colorectal cancer via miR-484/DLK1 axis.
      Title: LncRNA LINC01315 silencing modulates cancer stem cell properties and epithelial-to-mesenchymal transition in colorectal cancer via miR-484/DLK1 axis.
    4. LINC01315 promotes the aggressive phenotypes of papillary thyroid cancer cells by sponging miR-497-5p.
      Title: LINC01315 promotes the aggressive phenotypes of papillary thyroid cancer cells by sponging miR-497-5p.
    5. LINC01315 silencing inhibits the aggressive phenotypes of colorectal carcinoma by sponging miR-205-3p.
      Title: LINC01315 silencing inhibits the aggressive phenotypes of colorectal carcinoma by sponging miR-205-3p.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_120595.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AI914073, BC038245, CB050274
      Related
      ENST00000669665.3

    2. NR_120596.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' exon, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AI914073, AV709904, BC038245, CB050274
      Related
      ENST00000432473.4

    3. NR_120597.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses alternate splice sites at the 5' and 3' exons, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AI914073, CB050274
      Related
      ENST00000412060.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      42364400..42369208 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      42845402..42850211 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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