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    Smok3a sperm motility kinase 3A [ Mus musculus (house mouse) ]

    Gene ID: 545814, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Smok3aprovided by MGI
    Official Full Name
    sperm motility kinase 3Aprovided by MGI
    Primary source
    MGI:MGI:3693943
    See related
    Ensembl:ENSMUSG00000075599 AllianceGenome:MGI:3693943
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Smok2b1
    Summary
    Predicted to enable protein serine/threonine kinase activity and tau-protein kinase activity. Predicted to be involved in intracellular signal transduction and microtubule cytoskeleton organization. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 10.2) See more
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    Genomic context

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    See Smok3a in Genome Data Viewer
    Location:
    5 G2; 5 76.93 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (138019538..138032927)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (138021276..138034665)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene alpha-2-glycoprotein 1, zinc Neighboring gene predicted gene 4963 Neighboring gene STARR-seq mESC enhancer starr_14662 Neighboring gene STARR-seq mESC enhancer starr_14663 Neighboring gene sperm motility kinase 3B Neighboring gene sperm motility kinase 3C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A protein kinase encoded by the t complex responder gene causes non-mendelian inheritance. Herrmann BG, et al. Nature, 1999 Nov 11. PMID 10647005
    2. The transcriptional landscape of the mammalian genome. Carninci P, et al. Science, 2005 Sep 2. PMID 16141072
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sperm motility kinase 3A
    Names
    sperm motility kinase 2B1
    sperm motility kinase 3
    NP_001119517.1
    NP_001162073.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126045.1 → NP_001119517.1  sperm motility kinase 3A

      See identical proteins and their annotated locations for NP_001119517.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has a split 3' exon, as compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC125212
      Consensus CDS
      CCDS51678.1
      UniProtKB/Swiss-Prot
      C0HKC8, C0HKC9, Q9QYZ5
      UniProtKB/TrEMBL
      B9EKK5
      Related
      ENSMUSP00000125938.2, ENSMUST00000171498.3
      Conserved Domains (2) summary
      cd14337
      Location:295 → 334
      UBA_MARK_Par1; UBA domain found in microtubule-associated protein (MAP)/microtubule affinity-regulating kinase (MARK)/ partitioning-defective 1 (Par-1) and similar proteins
      cd14003
      Location:27 → 275
      STKc_AMPK-like; Catalytic domain of AMP-activated protein kinase-like Serine/Threonine Kinases

    2. NM_001168602.1 → NP_001162073.1  sperm motility kinase 3A

      See identical proteins and their annotated locations for NP_001162073.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC125212
      Consensus CDS
      CCDS51678.1
      UniProtKB/Swiss-Prot
      C0HKC8, C0HKC9, Q9QYZ5
      UniProtKB/TrEMBL
      B9EKK5
      Related
      ENSMUSP00000083049.3, ENSMUST00000085886.3
      Conserved Domains (2) summary
      cd14337
      Location:295 → 334
      UBA_MARK_Par1; UBA domain found in microtubule-associated protein (MAP)/microtubule affinity-regulating kinase (MARK)/ partitioning-defective 1 (Par-1) and similar proteins
      cd14003
      Location:27 → 275
      STKc_AMPK-like; Catalytic domain of AMP-activated protein kinase-like Serine/Threonine Kinases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      138019538..138032927
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C0HKC8.1 GenPept UniProtKB/Swiss-Prot:C0HKC8

    Gene LinkOut

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