stk11 serine/threonine kinase 11 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: stk11provided by ZNC
Official Full Name: serine/threonine kinase 11provided by ZNC
Primary source: ZFIN:ZDB-GENE-050417-383
See related: Ensembl:ENSDARG00000046074 AllianceGenome:ZFIN:ZDB-GENE-050417-383
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fj61a05; zgc:110180
Summary: Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within several processes, including energy homeostasis; glucose homeostasis; and intestinal epithelial cell differentiation. Predicted to be located in cytoplasm and nucleus. Is expressed in digestive system; head; and trunk. Human ortholog(s) of this gene implicated in Peutz-Jeghers syndrome; familial melanoma; female reproductive organ cancer (multiple); and pancreatic cancer. Orthologous to human STK11 (serine/threonine kinase 11). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (59041081..59063573)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (58943780..58966272)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

inactivation of zebrafish Lkb1 upregulates pyruvate dehydrogenase kinase 2 expression and inactivates pyruvate dehydrogenase complex by increasing phosphorylation of pyruvate dehydrogenase.
Title: The tumor suppressor gene lkb1 is essential for glucose homeostasis during zebrafish early development.
A critical role for LKB1 in regulating energy homeostasis at the whole-organism level in a vertebrate, is demonstrated.
Title: The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish.
Data suggest that programmed localization of Lkb1 could represent a novel mechanism for regulating the EIT during intestinal development in vertebrates.
Title: Dynamic Lkb1-TORC1 signaling as a possible mechanism for regulating the endoderm-intestine transition.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activator activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within digestive tract development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within energy homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of cell polarity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glucose homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intestinal epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of autophagy	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell growth	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/threonine-protein kinase STK11

Names: lkb1

NP_001017839.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017839.1 → NP_001017839.1 serine/threonine-protein kinase STK11

See identical proteins and their annotated locations for NP_001017839.1

Status: PROVISIONAL

Source sequence(s)

BC092776

UniProtKB/TrEMBL

Q568P5

Related

ENSDARP00000067735.4, ENSDART00000067736.6

Conserved Domains (2) summary

smart00220
Location:48 → 308

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14119
Location:54 → 308

STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1