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    Klhdc10 kelch domain containing 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312199, updated on 9-Dec-2024

    Summary

    Official Symbol
    Klhdc10provided by RGD
    Official Full Name
    kelch domain containing 10provided by RGD
    Primary source
    RGD:1309792
    See related
    EnsemblRapid:ENSRNOG00000010267 AllianceGenome:RGD:1309792
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309792
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in positive regulation of stress-activated MAPK cascade; rescue of stalled ribosome; and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Predicted to be located in nucleoplasm. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KLHDC10 (kelch domain containing 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 273.3), Brain (RPKM 233.6) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Klhdc10 in Genome Data Viewer
    Location:
    4q22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (59988710..60046518)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (59021300..59079118)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (57715982..57773800)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA32 Neighboring gene zinc finger, C3HC-type containing 1 Neighboring gene uncharacterized LOC134486570 Neighboring gene uncharacterized LOC108350685 Neighboring gene transmembrane protein 209

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-like ligase-substrate adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of Cul2-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Cul2-RING ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    kelch domain-containing protein 10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017456.1NP_001017456.1  kelch domain-containing protein 10

      See identical proteins and their annotated locations for NP_001017456.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085351
      UniProtKB/Swiss-Prot
      Q5U3Y0
      UniProtKB/TrEMBL
      A0A8I5ZRC5, A6IEG0
      Related
      ENSRNOP00000038586.4, ENSRNOT00000034429.6
      Conserved Domains (4) summary
      PLN02153
      Location:107270
      PLN02153; epithiospecifier protein
      PRK14131
      Location:56139
      PRK14131; N-acetylneuraminate epimerase
      sd00038
      Location:176224
      Kelch; KELCH repeat [structural motif]
      pfam01344
      Location:283329
      Kelch_1; Kelch motif

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      59988710..60046518
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236201.5XP_006236263.1  kelch domain-containing protein 10 isoform X1

      See identical proteins and their annotated locations for XP_006236263.1

      UniProtKB/TrEMBL
      A0A0G2KB15, A0A8I5ZRC5
      Related
      ENSRNOP00000106559.1, ENSRNOT00000096895.2
      Conserved Domains (4) summary
      PLN02153
      Location:136299
      PLN02153; epithiospecifier protein
      PRK14131
      Location:85168
      PRK14131; N-acetylneuraminate epimerase
      sd00038
      Location:205253
      Kelch; KELCH repeat [structural motif]
      pfam01344
      Location:312358
      Kelch_1; Kelch motif