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    Tspan4 tetraspanin 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293627, updated on 9-Dec-2024

    Summary

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    Symbol
    Tspan4provided by RGD
    Full Name
    tetraspanin 4provided by RGD
    Primary source
    RGD:1305810
    See related
    EnsemblRapid:ENSRNOG00000029810 AllianceGenome:RGD:1305810
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tm4sf7
    Summary
    Predicted to enable antigen binding activity and integrin binding activity. Predicted to be involved in protein-containing complex assembly. Predicted to act upstream of or within mitocytosis and regulation of mitochondrial membrane potential. Predicted to be located in migrasome and vesicle. Predicted to be active in plasma membrane. Orthologous to human TSPAN4 (tetraspanin 4). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Note: GeneIDs: 293627 and 100911766 are annotated independently on Rnor_6.0 but may be redundant loci. [13 Feb 2015]
    Expression
    Biased expression in Liver (RPKM 188.0), Spleen (RPKM 139.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tspan4 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (206001731..206021414)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (196571307..196593842)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (214454090..214473789)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene CD151 molecule (Raph blood group) Neighboring gene RNA polymerase II, I and III subunit L Neighboring gene chitinase domain containing 1 Neighboring gene RNA, U6 small nuclear 317

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins. Tachibana I, et al. J Biol Chem, 1997 Nov 14. PMID 9360996
    2. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Kuo JC, et al. Nat Cell Biol, 2011 Apr. PMID 21423176, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108789

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables antigen binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within mitocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in migrasome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tetraspanin-4
    Names
    tetraspanin-4-like
    transmembrane 4 superfamily member 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013070.1 → NP_001013088.1  tetraspanin-4

      See identical proteins and their annotated locations for NP_001013088.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091174
      UniProtKB/TrEMBL
      A6HY09, F7EW38, Q5BK80
      Related
      ENSRNOP00000043060.3, ENSRNOT00000049448.5
      Conserved Domains (2) summary
      cd03165
      Location:105 → 202
      NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
      pfam00335
      Location:9 → 226
      Tetraspannin; Tetraspanin family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      206001731..206021414
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230545.5 → XP_006230607.1  tetraspanin-4 isoform X2

      See identical proteins and their annotated locations for XP_006230607.1

      UniProtKB/TrEMBL
      A6HY09, F7EW38, Q5BK80
      Conserved Domains (2) summary
      cd03165
      Location:105 → 202
      NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
      pfam00335
      Location:9 → 226
      Tetraspannin; Tetraspanin family

    2. XM_063286618.1 → XP_063142688.1  tetraspanin-4 isoform X3

      UniProtKB/TrEMBL
      A6HY13

    3. XM_039108023.2 → XP_038963951.1  tetraspanin-4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y7S7
      Related
      ENSRNOP00000077465.1, ENSRNOT00000111602.2
      Conserved Domains (2) summary
      cd03165
      Location:200 → 297
      NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
      pfam00335
      Location:104 → 321
      Tetraspannin; Tetraspanin family

    RNA

    1. XR_005503279.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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