Aamdc adipogenesis associated Mth938 domain containing [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aamdcprovided by MGI
Official Full Name: adipogenesis associated Mth938 domain containingprovided by MGI
Primary source: MGI:MGI:1913523
See related: Ensembl:ENSMUSG00000035642 AllianceGenome:MGI:1913523
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LI2; 1810020D17Rik; 1810037D19Rik
Summary: Acts upstream of or within negative regulation of apoptotic process; positive regulation of fat cell differentiation; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm. Is expressed in central nervous system; embryo; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human AAMDC (adipogenesis associated Mth938 domain containing). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in subcutaneous fat pad adult (RPKM 15.8), kidney adult (RPKM 15.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E1; 7 53.54 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (97199538..97228723, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (97550329..97579557, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fat cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: mth938 domain-containing protein

Names: UPF0366 protein C11orf67 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001177945.1 → NP_001171416.1 mth938 domain-containing protein isoform 1

See identical proteins and their annotated locations for NP_001171416.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC149605, AW124043, BC062811, BY259812

Consensus CDS

CCDS52316.1

UniProtKB/TrEMBL

D3YWY5, D3YZD8

Related

ENSMUSP00000115672.2, ENSMUST00000154853.8

Conserved Domains (1) summary

cd05126
Location:33 → 148

Mth938; Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the ...
NM_001177946.1 → NP_001171417.1 mth938 domain-containing protein isoform 3

See identical proteins and their annotated locations for NP_001171417.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.

Source sequence(s)

AC149605, BC062811, BY259812

Consensus CDS

CCDS52315.1

UniProtKB/TrEMBL

D3Z1Q3

Related

ENSMUSP00000072508.6, ENSMUST00000072725.12

Conserved Domains (1) summary

cl00182
Location:33 → 116

Mth938-like; Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a ...
NM_001177947.1 → NP_001171418.1 mth938 domain-containing protein isoform 4

See identical proteins and their annotated locations for NP_001171418.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks two coding exons, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.

Source sequence(s)

AC149605, AK008195, BC062811, BY259812

Consensus CDS

CCDS52314.1

UniProtKB/Swiss-Prot

Q8R0P4

Related

ENSMUSP00000116214.2, ENSMUST00000138060.3

Conserved Domains (1) summary

cl00182
Location:5 → 88

Mth938-like; Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a ...
NM_183251.3 → NP_899074.2 mth938 domain-containing protein isoform 2

See identical proteins and their annotated locations for NP_899074.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AA065573, AC149605, BC062811, BY259812

Consensus CDS

CCDS21461.1

UniProtKB/Swiss-Prot

Q8BH71, Q8R0P4

UniProtKB/TrEMBL

D3Z442

Related

ENSMUSP00000121940.2, ENSMUST00000136757.8

Conserved Domains (1) summary

cd05126
Location:5 → 120

Mth938; Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

97199538..97228723 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006508114.5 → XP_006508177.1 mth938 domain-containing protein isoform X1

See identical proteins and their annotated locations for XP_006508177.1

UniProtKB/Swiss-Prot

Q8BH71, Q8R0P4

UniProtKB/TrEMBL

D3Z442

Conserved Domains (1) summary

cd05126
Location:5 → 120

Mth938; Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the ...