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    Syt14 synaptotagmin XIV [ Mus musculus (house mouse) ]

    Gene ID: 329324, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Syt14provided by MGI
    Official Full Name
    synaptotagmin XIVprovided by MGI
    Primary source
    MGI:MGI:2444490
    See related
    Ensembl:ENSMUSG00000016200 AllianceGenome:MGI:2444490
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    sytXIV; B230320I09Rik
    Summary
    This gene encodes a member of the synaptotagmin family. The encoded protein may be involved in membrane trafficking. Disruption of a similar gene in human has been associated with autosomal recessive spinocerebellar ataxia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
    Expression
    Broad expression in liver E14 (RPKM 2.1), liver E14.5 (RPKM 1.9) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Syt14 in Genome Data Viewer
    Location:
    1 H6; 1 97.55 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (192564956..192718179, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (192882653..193035871, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700065J18 gene Neighboring gene SERTA domain containing 4 Neighboring gene STARR-seq mESC enhancer starr_03467 Neighboring gene predicted gene 15867 Neighboring gene STARR-seq mESC enhancer starr_03468 Neighboring gene 40S ribosomal protein S11-like Neighboring gene predicted gene, 39746 Neighboring gene predicted gene, 31406 Neighboring gene predicted gene, 39747 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:194913524-194913725 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:194948976-194949260 Neighboring gene STARR-positive B cell enhancer ABC_E3355 Neighboring gene UTP25 small subunit processome component

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning, expression, and characterization of a novel class of synaptotagmin (Syt XIV) conserved from Drosophila to humans. Fukuda M. J Biochem, 2003 May. PMID 12801916
    2. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables calcium-dependent phospholipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    synaptotagmin-14

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301370.1 → NP_001288299.1  synaptotagmin-14 isoform 1

      See identical proteins and their annotated locations for NP_001288299.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK045901, AK047918, AL365326, AW121643, BC141262
      Consensus CDS
      CCDS78780.1
      UniProtKB/TrEMBL
      B7ZP31
      Related
      ENSMUSP00000016344.9, ENSMUST00000016344.9
      Conserved Domains (2) summary
      cd08389
      Location:260 → 383
      C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
      cd08408
      Location:416 → 572
      C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16

    2. NM_181546.3 → NP_853524.1  synaptotagmin-14 isoform 2

      See identical proteins and their annotated locations for NP_853524.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
      Source sequence(s)
      AK045901, AK047918, AL365326, AW121643, BC145602
      Consensus CDS
      CCDS48489.1
      UniProtKB/Swiss-Prot
      Q7TN84
      Related
      ENSMUSP00000142190.2, ENSMUST00000195354.6
      Conserved Domains (2) summary
      cd08389
      Location:260 → 383
      C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
      cd08408
      Location:416 → 553
      C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      192564956..192718179 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255031.2 → XP_030110891.1  synaptotagmin-14 isoform X8

      Conserved Domains (2) summary
      cd08389
      Location:133 → 256
      C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
      cd08408
      Location:289 → 426
      C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16

    2. XM_011238938.3 → XP_011237240.1  synaptotagmin-14 isoform X7

      Conserved Domains (2) summary
      cd08389
      Location:133 → 256
      C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
      cd08408
      Location:289 → 445
      C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16

    3. XM_030255032.2 → XP_030110892.1  synaptotagmin-14 isoform X9

      Conserved Domains (2) summary
      cd08389
      Location:107 → 230
      C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
      cd08408
      Location:263 → 419
      C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16

    4. XM_036165952.1 → XP_036021845.1  synaptotagmin-14 isoform X4

      Conserved Domains (2) summary
      cd08389
      Location:222 → 345
      C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
      cd08408
      Location:378 → 534
      C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16

    5. XM_030255030.2 → XP_030110890.1  synaptotagmin-14 isoform X4

      Conserved Domains (2) summary
      cd08389
      Location:222 → 345
      C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
      cd08408
      Location:378 → 534
      C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16

    6. XM_006497256.3 → XP_006497319.1  synaptotagmin-14 isoform X2

      UniProtKB/TrEMBL
      A0A1L1SVE7
      Related
      ENSMUSP00000151129.2, ENSMUST00000215093.2
      Conserved Domains (2) summary
      cd08389
      Location:543 → 666
      C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
      cd08408
      Location:699 → 836
      C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16

    7. XM_006497255.3 → XP_006497318.1  synaptotagmin-14 isoform X1

      Conserved Domains (2) summary
      cd08389
      Location:543 → 666
      C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
      cd08408
      Location:699 → 855
      C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16

    8. XM_030255033.2 → XP_030110893.1  synaptotagmin-14 isoform X10

      Conserved Domains (1) summary
      cd08389
      Location:222 → 345
      C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16

    9. XM_006497257.1 → XP_006497320.1  synaptotagmin-14 isoform X3

      Conserved Domains (1) summary
      cd08389
      Location:543 → 666
      C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16

    10. XM_036165957.1 → XP_036021850.1  synaptotagmin-14 isoform X5

    11. XM_011238937.2 → XP_011237239.1  synaptotagmin-14 isoform X6

    RNA

    1. XR_003956138.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TN84.1 GenPept UniProtKB/Swiss-Prot:Q7TN84

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