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    MROH7-TTC4 MROH7-TTC4 readthrough (NMD candidate) [ Homo sapiens (human) ]

    Gene ID: 100527960, updated on 17-Sep-2024

    Summary

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    Official Symbol
    MROH7-TTC4provided by HGNC
    Official Full Name
    MROH7-TTC4 readthrough (NMD candidate)provided by HGNC
    Primary source
    HGNC:HGNC:49180
    See related
    Ensembl:ENSG00000271723 AllianceGenome:HGNC:49180
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MROH7; HEATR8; C1orf175; HEATR8-TTC4
    Summary
    This locus represents naturally occurring read-through transcription between the neighboring MROH7 (maestro heat-like repeat family member 7) and TTC4 (tetratricopeptide repeat domain 4) genes. Alternative splicing results in multiple transcript variants, which are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to produce protein products. [provided by RefSeq, Aug 2013]
    Expression
    Broad expression in testis (RPKM 32.6), ovary (RPKM 4.1) and 22 other tissues See more
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    Genomic context

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    See MROH7-TTC4 in Genome Data Viewer
    Location:
    1p32.3
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (54641740..54742657)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (54521968..54622890)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (55107413..55208330)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 920 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 63 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:55035141-55035653 Neighboring gene acyl-CoA thioesterase 11 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:55037069-55037592 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:55037593-55038114 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:55044894-55045404 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:55045405-55045913 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55059979-55060801 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1065 Neighboring gene family with sequence similarity 151 member A Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:55102633-55103264 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:55106005-55106518 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:55106519-55107031 Neighboring gene MPRA-validated peak242 silencer Neighboring gene maestro heat like repeat family member 7 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:55145240-55146100 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55163752-55164252 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55164253-55164753 Neighboring gene MPRA-validated peak243 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:55181271-55181772 Neighboring gene tetratricopeptide repeat domain 4 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:55229956-55230579 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55246797-55247339 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55247340-55247881 Neighboring gene prolyl-tRNA synthetase 2, mitochondrial Neighboring gene uncharacterized LOC124904182 Neighboring gene Sharpr-MPRA regulatory region 10932 Neighboring gene tetratricopeptide repeat domain 22

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A genome-wide association study of behavioral disinhibition. McGue M, et al. Behav Genet, 2013 Sep. PMID 23942779, Free PMC Article
    2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. Prakash T, et al. PLoS One, 2010 Oct 12. PMID 20967262, Free PMC Article
    3. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. Choudhury NR, et al. BMC Biol, 2017 Nov 8. PMID 29117863, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study of behavioral disinhibition.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough MROH7-TTC4

    Included genes: TTC4, MROH7

    Other Names

    • HEAT repeat-containing protein 8
    • HEATR8-TTC4 readthrough
    • Maestro heat-like repeat-containing protein family member 7

    Clone Names

    • FLJ20619, FLJ45063, FLJ46354, DKFZp686L2332, DKFZp781B0622

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_037639.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AL139244, AL590093, BC028620, BX648088, CR749830
      Related
      ENST00000425300.6

    2. NR_037640.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon and uses two alternate splice sites in the 5' region, and includes an additional exon in the central region, compared to variant 1.
      Source sequence(s)
      AL139244, AL590093, BX648088
      Related
      ENST00000414150.6

    3. NR_037641.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site and lacks an alternate exon in the 5' region, uses an alternate splice site and lacks an alternate exon but includes a different alternate exon in the central region, and lacks an alternate segment in the 3' region, compared to variant 1.
      Source sequence(s)
      AL139244, AL590093, BC028620
      Related
      ENST00000606515.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      54641740..54742657
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      54521968..54622890
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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