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    Muc15 mucin 15 [ Mus musculus (house mouse) ]

    Gene ID: 269328, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Muc15provided by MGI
    Official Full Name
    mucin 15provided by MGI
    Primary source
    MGI:MGI:2442110
    See related
    Ensembl:ENSMUSG00000050808 AllianceGenome:MGI:2442110
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MUC-15; 4732460E09; D730046L02Rik
    Summary
    Predicted to be located in membrane. Is expressed in genitourinary system. Orthologous to human MUC15 (mucin 15, cell surface associated). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward genital fat pad adult (RPKM 52.9) See more
    Orthologs
    human all
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    Genomic context

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    See Muc15 in Genome Data Viewer
    Location:
    2 E3; 2 56.75 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (110551839..110569882)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (110721494..110739537)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05369 Neighboring gene STARR-seq mESC enhancer starr_05370 Neighboring gene ribosomal protein S3A pseudogene Neighboring gene STARR-seq mESC enhancer starr_05371 Neighboring gene STARR-seq mESC enhancer starr_05372 Neighboring gene solute carrier family 5 (sodium/glucose cotransporter), member 12 Neighboring gene predicted gene, 52522 Neighboring gene anoctamin 3 Neighboring gene STARR-seq mESC enhancer starr_05373 Neighboring gene POTE ankyrin domain family member 1 Neighboring gene RB1-inducible coiled-coil 1 pseudogene Neighboring gene olfactory receptor family 4 subfamily F member 52

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Downregulation of MUC15 by miR-183-5p.1 promotes liver tumor-initiating cells properties and tumorigenesis via regulating c-MET/PI3K/AKT/SOX2 axis. Han T, et al. Cell Death Dis, 2022 Mar 2. PMID 35236826, Free PMC Article
    2. Impact of maternal obesity on placental transcriptome and morphology associated with fetal growth restriction in mice. de Barros Mucci D, et al. Int J Obes (Lond), 2020 May. PMID 32203108, Free PMC Article
    3. Analysis of Pax6 contiguous gene deletions in the mouse, Mus musculus, identifies regions distinct from Pax6 responsible for extreme small-eye and belly-spotting phenotypes. Favor J, et al. Genetics, 2009 Aug. PMID 19474196, Free PMC Article
    4. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mucin-15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290786.1 → NP_001277715.1  mucin-15 isoform b precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AK028832, AK142590, AL731779
      Consensus CDS
      CCDS71111.1
      UniProtKB/TrEMBL
      A2AHK7, Q505K5
      Related
      ENSMUSP00000106646.3, ENSMUST00000111017.9
      Conserved Domains (1) summary
      pfam15672
      Location:23 → 279
      Mucin15; Cell-membrane associated Mucin15

    2. NM_172979.3 → NP_766567.1  mucin-15 isoform a precursor

      See identical proteins and their annotated locations for NP_766567.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK028832, AK142590, AL731779
      Consensus CDS
      CCDS16513.1
      UniProtKB/Swiss-Prot
      Q3UQC4, Q6XYQ9, Q7TMH6, Q8C6Z1, Q8CE82
      UniProtKB/TrEMBL
      Q0VEM9, Q14AL4
      Related
      ENSMUSP00000106645.3, ENSMUST00000111016.9
      Conserved Domains (1) summary
      pfam15672
      Location:23 → 331
      Mucin15; Cell-membrane associated Mucin15

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      110551839..110569882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C6Z1.1 GenPept UniProtKB/Swiss-Prot:Q8C6Z1

    Gene LinkOut

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