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    Pacsin3 protein kinase C and casein kinase substrate in neurons 3 [ Mus musculus (house mouse) ]

    Gene ID: 80708, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pacsin3provided by MGI
    Official Full Name
    protein kinase C and casein kinase substrate in neurons 3provided by MGI
    Primary source
    MGI:MGI:1891410
    See related
    Ensembl:ENSMUSG00000027257 AllianceGenome:MGI:1891410
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4921507A02Rik; 6330413E15Rik
    Summary
    Enables calcium channel inhibitor activity; cytoskeletal protein binding activity; and lipid binding activity. Involved in negative regulation of calcium ion transport and plasma membrane tubulation. Acts upstream of or within negative regulation of endocytosis. Located in cytoplasm. Is expressed in central nervous system and retina. Orthologous to human PACSIN3 (protein kinase C and casein kinase substrate in neurons 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 20.1), cerebellum adult (RPKM 14.4) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pacsin3 in Genome Data Viewer
    Location:
    2 E1; 2 50.61 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (91086215..91095025)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (91255875..91264680)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A330069E16 gene Neighboring gene STARR-positive B cell enhancer ABC_E8985 Neighboring gene predicted gene, 31054 Neighboring gene STARR-positive B cell enhancer ABC_E3385 Neighboring gene ARF GTPase activating protein 2 Neighboring gene centriolar satellite-associated tubulin polyglutamylase complex regulator 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:91148974-91149175 Neighboring gene predicted gene 13787

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium channel inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables cytoskeletal protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables lipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    NOT located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein kinase C and casein kinase II substrate protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289677.1NP_001276606.1  protein kinase C and casein kinase II substrate protein 3

      See identical proteins and their annotated locations for NP_001276606.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 through 4 encode the same protein.
      Source sequence(s)
      AK049166, AK078060, AV333674
      Consensus CDS
      CCDS16429.1
      UniProtKB/Swiss-Prot
      Q99JB8, Q9EQP9
      UniProtKB/TrEMBL
      Q543N7
      Related
      ENSMUSP00000054391.5, ENSMUST00000059566.11
      Conserved Domains (2) summary
      cd11997
      Location:365420
      SH3_PACSIN3; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 3 (PACSIN3)
      cl12013
      Location:16273
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. NM_001289678.1NP_001276607.1  protein kinase C and casein kinase II substrate protein 3

      See identical proteins and their annotated locations for NP_001276607.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1 through 4 encode the same protein.
      Source sequence(s)
      AF149824, AK049166, AV333674, BY250979
      Consensus CDS
      CCDS16429.1
      UniProtKB/Swiss-Prot
      Q99JB8, Q9EQP9
      UniProtKB/TrEMBL
      Q543N7
      Related
      ENSMUSP00000028694.6, ENSMUST00000028694.12
      Conserved Domains (2) summary
      cd11997
      Location:365420
      SH3_PACSIN3; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 3 (PACSIN3)
      cl12013
      Location:16273
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    3. NM_028733.4NP_083009.1  protein kinase C and casein kinase II substrate protein 3

      See identical proteins and their annotated locations for NP_083009.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 through 4 encode the same protein.
      Source sequence(s)
      AK049166, AV333674
      Consensus CDS
      CCDS16429.1
      UniProtKB/Swiss-Prot
      Q99JB8, Q9EQP9
      UniProtKB/TrEMBL
      Q543N7
      Related
      ENSMUSP00000106981.3, ENSMUST00000111349.9
      Conserved Domains (2) summary
      cd11997
      Location:365420
      SH3_PACSIN3; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 3 (PACSIN3)
      cl12013
      Location:16273
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    4. NM_030880.3NP_112019.2  protein kinase C and casein kinase II substrate protein 3

      See identical proteins and their annotated locations for NP_112019.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1 through 4 encode the same protein.
      Source sequence(s)
      AK141063, AV333674, BY250979
      Consensus CDS
      CCDS16429.1
      UniProtKB/Swiss-Prot
      Q99JB8, Q9EQP9
      UniProtKB/TrEMBL
      Q543N7
      Related
      ENSMUSP00000129175.2, ENSMUST00000168916.8
      Conserved Domains (2) summary
      cd11997
      Location:365420
      SH3_PACSIN3; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 3 (PACSIN3)
      cl12013
      Location:16273
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      91086215..91095025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252256.2XP_030108116.1  protein kinase C and casein kinase II substrate protein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q99JB8, Q9EQP9
      UniProtKB/TrEMBL
      Q543N7
      Conserved Domains (2) summary
      cd11997
      Location:365420
      SH3_PACSIN3; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 3 (PACSIN3)
      cl12013
      Location:16273
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. XM_006500427.5XP_006500490.1  protein kinase C and casein kinase II substrate protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006500490.1

      UniProtKB/Swiss-Prot
      Q99JB8, Q9EQP9
      UniProtKB/TrEMBL
      Q543N7
      Conserved Domains (2) summary
      cd11997
      Location:365420
      SH3_PACSIN3; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 3 (PACSIN3)
      cl12013
      Location:16273
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    3. XM_006500425.1XP_006500488.1  protein kinase C and casein kinase II substrate protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006500488.1

      UniProtKB/Swiss-Prot
      Q99JB8, Q9EQP9
      UniProtKB/TrEMBL
      Q543N7
      Conserved Domains (2) summary
      cd11997
      Location:365420
      SH3_PACSIN3; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 3 (PACSIN3)
      cl12013
      Location:16273
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    4. XM_006500428.5XP_006500491.1  protein kinase C and casein kinase II substrate protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006500491.1

      UniProtKB/Swiss-Prot
      Q99JB8, Q9EQP9
      UniProtKB/TrEMBL
      Q543N7
      Conserved Domains (2) summary
      cd11997
      Location:365420
      SH3_PACSIN3; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 3 (PACSIN3)
      cl12013
      Location:16273
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    5. XM_006500424.5XP_006500487.1  protein kinase C and casein kinase II substrate protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006500487.1

      UniProtKB/Swiss-Prot
      Q99JB8, Q9EQP9
      UniProtKB/TrEMBL
      Q543N7
      Conserved Domains (2) summary
      cd11997
      Location:365420
      SH3_PACSIN3; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 3 (PACSIN3)
      cl12013
      Location:16273
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature