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    nr2e1 nuclear receptor subfamily 2, group E, member 1 [ Danio rerio (zebrafish) ]

    Gene ID: 445214, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nr2e1provided by ZNC
    Official Full Name
    nuclear receptor subfamily 2, group E, member 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040801-127
    See related
    Ensembl:ENSDARG00000017107 AllianceGenome:ZFIN:ZDB-GENE-040801-127
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    tlx; fc30e03; fc39f12; wu:fc30e03; wu:fc39f12; zgc:100991
    Summary
    Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in cell differentiation and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in several structures, including alar plate midbrain region; nervous system; optic vesicle; presumptive diencephalon; and presumptive neural retina. Orthologous to human NR2E1 (nuclear receptor subfamily 2 group E member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See nr2e1 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (32437398..32446399, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (32534519..32543520, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene AFG1 like ATPase b Neighboring gene sorting nexin 3 Neighboring gene uncharacterized LOC137488663 Neighboring gene osteoclastogenesis associated transmembrane protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The zebrafish orphan nuclear receptor genes nr2e1 and nr2e3 are expressed in developing eye and forebrain. Kitambi SS, et al. Gene Expr Patterns, 2007 Feb. PMID 17127102
    2. MicroRNA-9 Couples Brain Neurogenesis and Angiogenesis. Madelaine R, et al. Cell Rep, 2017 Aug 15. PMID 28813666, Free PMC Article
    3. G-quadruplexes as novel cis-elements controlling transcription during embryonic development. David AP, et al. Nucleic Acids Res, 2016 May 19. PMID 26773060, Free PMC Article
    4. Mutation of vsx genes in zebrafish highlights the robustness of the retinal specification network. Letelier J, et al. Elife, 2023 May 25. PMID 37227126, Free PMC Article
    5. Genome-wide identification, evolution and expression analysis of nuclear receptor superfamily in Nile tilapia, Oreochromis niloticus. Cheng YY, et al. Gene, 2015 Sep 10. PMID 26024593

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nuclear receptor subfamily 2 group E member 1
    Names
    NR2D1
    TLL

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003608.1 → NP_001003608.1  nuclear receptor subfamily 2 group E member 1

      See identical proteins and their annotated locations for NP_001003608.1

      Status: PROVISIONAL

      Source sequence(s)
      BC077146
      UniProtKB/TrEMBL
      A0FIJ8, Q6DEH0
      Related
      ENSDARP00000013317.6, ENSDART00000026635.7
      Conserved Domains (2) summary
      cd06950
      Location:165 → 380
      NR_LBD_Tlx_PNR_like; The ligand binding domain of Tailless-like proteins, orphan nuclear receptors
      cd07163
      Location:19 → 110
      NR_DBD_TLX; DNA-binding domain of Tailless (TLX) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      32437398..32446399 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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