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    Pla2g7 phospholipase A2 group VII [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301265, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pla2g7provided by RGD
    Official Full Name
    phospholipase A2 group VIIprovided by RGD
    Primary source
    RGD:1310734
    See related
    EnsemblRapid:ENSRNOG00000025691 AllianceGenome:RGD:1310734
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 1-alkyl-2-acetylglycerophosphocholine esterase activity; calcium-independent phospholipase A2 activity; and phospholipid binding activity. Predicted to be involved in several processes, including glycerophospholipid catabolic process; plasma lipoprotein particle remodeling; and positive regulation of monocyte chemotaxis. Located in extracellular space. Biomarker of nephrotic syndrome. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); glomerulonephritis (multiple); hemolytic-uremic syndrome; proteinuria (multiple); and type 2 diabetes mellitus. Orthologous to human PLA2G7 (phospholipase A2 group VII). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 34.6), Spleen (RPKM 29.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pla2g7 in Genome Data Viewer
    Location:
    9q13
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (24859491..24901747, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (17362214..17404476, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (19935754..19978013, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 25, member 27 Neighboring gene tudor domain containing 6 Neighboring gene uncharacterized LOC134480345 Neighboring gene uncharacterized LOC120094640 Neighboring gene ankyrin repeat domain 66 Neighboring gene meprin A subunit alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Lipoprotein-associated phospholipase A2 (Lp-PLA2) and future risk of type 2 diabetes: results from the Cardiovascular Health Study. Nelson TL, et al. J Clin Endocrinol Metab, 2012 May. PMID 22399516, Free PMC Article
    2. Changes in glycerophospholipid profile in experimental nephrotic syndrome. Mimura K, et al. Metabolism, 1996 Jul. PMID 8692015
    3. Platelet-activating factor levels and PAF acetylhydrolase activities in patients with primary glomerulonephritis. Iatrou C, et al. Nephron, 1996. PMID 8730430
    4. Platelet-activating factor acetylhydrolase gene mutation in Japanese nephrotic children. Xu H, et al. Kidney Int, 1998 Dec. PMID 9853251
    5. Role of platelet-activating factor acetylhydrolase gene mutation in Japanese childhood IgA nephropathy. Tanaka R, et al. Am J Kidney Dis, 1999 Aug. PMID 10430976

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show an increase of liver group VII phospholipase A2 gene expression in the obese animals together with a strong specific inhibition of type IVA and VIA phospholipases A2.
      Title: The metabolic cascade leading to eicosanoid precursors--desaturases, elongases, and phospholipases A2--is altered in Zucker fatty rats.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Clone Names

    • MGC95107

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-alkyl-2-acetylglycerophosphocholine esterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium-independent phospholipase A2 activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in lipid oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in low-density lipoprotein particle remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylcholine catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in plasma lipoprotein particle oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in platelet activating factor catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in platelet activating factor metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of monocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of high-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of low-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    platelet-activating factor acetylhydrolase
    Names
    phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
    NP_001009353.1
    XP_006244668.1
    XP_063122939.1
    XP_063122940.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009353.1 → NP_001009353.1  platelet-activating factor acetylhydrolase precursor

      See identical proteins and their annotated locations for NP_001009353.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088457
      UniProtKB/TrEMBL
      A0A8I6GE94, A6JJ34, A6JJ35, Q5M7T7
      Related
      ENSRNOP00000031958.3, ENSRNOT00000038222.6
      Conserved Domains (1) summary
      pfam03403
      Location:47 → 415
      PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      24859491..24901747 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266869.1 → XP_063122939.1  platelet-activating factor acetylhydrolase isoform X2

      UniProtKB/TrEMBL
      A0A8I6GE94
      Related
      ENSRNOP00000107961.1, ENSRNOT00000138099.1

    2. XM_006244606.5 → XP_006244668.1  platelet-activating factor acetylhydrolase isoform X1

      UniProtKB/TrEMBL
      A0A8I6GE94
      Related
      ENSRNOP00000085766.2, ENSRNOT00000119925.2
      Conserved Domains (1) summary
      pfam03403
      Location:80 → 448
      PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II

    3. XM_063266870.1 → XP_063122940.1  platelet-activating factor acetylhydrolase isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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