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    Il4 interleukin 4 [ Mus musculus (house mouse) ]

    Gene ID: 16189, updated on 27-Nov-2024

    Summary

    Official Symbol
    Il4provided by MGI
    Official Full Name
    interleukin 4provided by MGI
    Primary source
    MGI:MGI:96556
    See related
    Ensembl:ENSMUSG00000000869 AllianceGenome:MGI:96556
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Il-4; BSF-1
    Summary
    Enables cytokine activity. Involved in several processes, including innate immune response in mucosa; negative regulation of white fat cell proliferation; and regulation of gene expression. Acts upstream of or within several processes, including T-helper cell differentiation; positive regulation of macromolecule metabolic process; and regulation of lymphocyte activation. Located in external side of plasma membrane and extracellular space. Is expressed in several structures, including brain; gut; hemolymphoid system gland; liver; and placenta. Used to study Sjogren's syndrome; atopic dermatitis; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); hepatitis B; hepatitis C; and pancreatic cancer (multiple). Orthologous to human IL4 (interleukin 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Il4 in Genome Data Viewer
    Location:
    11 B1.3; 11 31.97 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (53503287..53509492, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (53612460..53618665, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene septin 8 Neighboring gene cyclin-like Neighboring gene RIKEN cDNA A430108G06 gene Neighboring gene kinesin family member 3A Neighboring gene STARR-seq mESC enhancer starr_29488 Neighboring gene STARR-seq mESC enhancer starr_29489 Neighboring gene origin of replication in Il13 Neighboring gene interleukin 13 Neighboring gene ribosomal protein S2, pseudogene 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (7) 
    • Targeted (18)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cytokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables interleukin-4 receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of B cell activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within B cell costimulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of B cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of MHC class II biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within T-helper 1 cell lineage commitment IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within T-helper 2 cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of activated T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in activation of Janus kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cholesterol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within defense response to protozoan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dendritic cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of extrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in innate immune response in mucosa IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in interleukin-4-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in interleukin-4-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of isotype switching to IgE isotypes IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of isotype switching to IgG isotypes IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in macrophage activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microglial cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in myeloid dendritic cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of T cell activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of T-helper 17 cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of acute inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cellular response to transforming growth factor beta stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of chronic inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of complement-dependent cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endothelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of macrophage activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of osteoclast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of white fat cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neuroinflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of ATP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of B cell activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of B cell chemotaxis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of B cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of MHC class II biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of T-helper 2 cell cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of activated T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of amyloid-beta clearance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of amyloid-beta clearance ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cellular respiration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of chemokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of defense response to virus by host ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of eosinophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of immunoglobulin production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of immunoglobulin production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interleukin-10 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-13 production ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of isotype switching to IgE isotypes IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of isotype switching to IgG isotypes IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of macroautophagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of mast cell degranulation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of mast cell degranulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mononuclear cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of myoblast fusion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of reactive oxygen species biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of receptor-mediated endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of tyrosine phosphorylation of STAT protein IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of proton transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to nematode IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to selenium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of tyrosine phosphorylation of STAT protein IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    interleukin-4
    Names
    B-cell IgG differentiation factor
    B-cell growth factor 1
    B-cell stimulatory factor 1
    IGG1 induction factor
    lymphocyte stimulatory factor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021283.2NP_067258.1  interleukin-4 precursor

      See identical proteins and their annotated locations for NP_067258.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
      Source sequence(s)
      BC027514, M25892
      Consensus CDS
      CCDS24682.1
      UniProtKB/Swiss-Prot
      P07750
      UniProtKB/TrEMBL
      Q91Y50
      Related
      ENSMUSP00000000889.7, ENSMUST00000000889.7
      Conserved Domains (1) summary
      smart00190
      Location:1140
      IL4_13; Interleukins 4 and 13

    RNA

    1. NR_027491.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AA199406, BC027514, BX529138
      Related
      ENSMUST00000150568.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      53503287..53509492 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)