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    Zfp383 zinc finger protein 383 [ Mus musculus (house mouse) ]

    Gene ID: 73729, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp383provided by MGI
    Official Full Name
    zinc finger protein 383provided by MGI
    Primary source
    MGI:MGI:1920979
    See related
    Ensembl:ENSMUSG00000099689 AllianceGenome:MGI:1920979
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110003H10Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nuclear membrane and nucleoplasm. Predicted to be active in nucleus. Is expressed in cerebral cortex ventricular layer. Orthologous to human ZNF383 (zinc finger protein 383). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in whole brain E14.5 (RPKM 5.0), CNS E14 (RPKM 4.9) and 19 other tissues See more
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    Genomic context

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    See Zfp383 in Genome Data Viewer
    Location:
    7 B1; 7 17.26 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (29607705..29616238)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (29908280..29916813)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10434 Neighboring gene zinc finger protein 420 Neighboring gene STARR-seq mESC enhancer starr_18494 Neighboring gene zinc finger protein 27 Neighboring gene STARR-positive B cell enhancer ABC_E9288 Neighboring gene microRNA 7668 Neighboring gene STARR-seq mESC enhancer starr_18496 Neighboring gene zinc finger protein 74 Neighboring gene RIKEN cDNA C230062I16 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:30738577-30738760 Neighboring gene STARR-positive B cell enhancer ABC_E8160 Neighboring gene predicted gene, 57504 Neighboring gene macrophage migration inhibitory factor, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    2. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 383

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243908.1 → NP_001230837.1  zinc finger protein 383

      Status: VALIDATED

      Source sequence(s)
      AC149283
      Consensus CDS
      CCDS80690.1
      UniProtKB/TrEMBL
      A0A087WRR7
      Related
      ENSMUSP00000140742.2, ENSMUST00000186475.2
      Conserved Domains (6) summary
      smart00349
      Location:27 → 87
      KRAB; krueppel associated box
      COG5048
      Location:246 → 490
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:327 → 347
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:437 → 459
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:27 → 66
      KRAB; KRAB box
      pfam13465
      Location:367 → 392
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      29607705..29616238
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250725.2 → XP_011249027.1  zinc finger protein 383 isoform X2

      Conserved Domains (5) summary
      smart00349
      Location:12 → 72
      KRAB; krueppel associated box
      COG5048
      Location:231 → 475
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:312 → 332
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:170 → 192
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:212 → 237
      zf-H2C2_2; Zinc-finger double domain

    2. XM_006540391.1 → XP_006540454.1  zinc finger protein 383 isoform X1

      Conserved Domains (5) summary
      smart00349
      Location:35 → 95
      KRAB; krueppel associated box
      COG5048
      Location:254 → 498
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:335 → 355
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:193 → 215
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:235 → 260
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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