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    Homer1 homer scaffold protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29546, updated on 9-Dec-2024

    Summary

    Official Symbol
    Homer1provided by RGD
    Official Full Name
    homer scaffold protein 1provided by RGD
    Primary source
    RGD:628725
    See related
    EnsemblRapid:ENSRNOG00000047014 AllianceGenome:RGD:628725
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Vesl-1; HOMER1F
    Summary
    Enables several functions, including identical protein binding activity; scaffold protein binding activity; and type 5 metabotropic glutamate receptor binding activity. A structural constituent of postsynapse. Involved in several processes, including G protein-coupled glutamate receptor signaling pathway; protein tetramerization; and regulation of dendritic spine maintenance. Located in dendrite; excitatory synapse; and neuronal cell body. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human HOMER1 (homer scaffold protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 230.8), Muscle (RPKM 185.0) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Homer1 in Genome Data Viewer
    Location:
    2q12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (26279012..26388279)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (24542777..24645715)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (22909550..23012303)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485574 Neighboring gene uncharacterized LOC134485573 Neighboring gene uncharacterized LOC103691422 Neighboring gene junction mediating and regulatory protein, p53 cofactor Neighboring gene uncharacterized LOC134485817 Neighboring gene uncharacterized LOC102548141

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled glutamate receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled glutamate receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables G protein-coupled glutamate receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables molecular adaptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables scaffold protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables structural constituent of postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables structural constituent of postsynapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables transmembrane transporter binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables type 5 metabotropic glutamate receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled glutamate receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in G protein-coupled glutamate receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in G protein-coupled glutamate receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in behavioral response to cocaine IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within behavioral response to cocaine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in positive regulation of calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in postsynapse organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein tetramerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of calcium ion import IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of calcium ion import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cation channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of dendritic spine maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of dendritic spine maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of postsynaptic neurotransmitter receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of store-operated calcium entry IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of store-operated calcium entry IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of store-operated calcium entry ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of synaptic transmission, glutamatergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of synaptic transmission, glutamatergic ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to cocaine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to nicotine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in skeletal muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within skeletal muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in skeletal muscle fiber development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within skeletal muscle fiber development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Z disc ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical part of cell IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in costamere IEA
    Inferred from Electronic Annotation
    more info
     
    located_in costamere ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic shaft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in excitatory synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    homer protein homolog 1
    Names
    PSD-Zip45
    VASP/Ena-related gene up-regulated during seizure and LTP 1
    homer homolog 1
    homer scaffolding protein 1
    homer, neuronal immediate early gene, 1
    scaffold protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031707.2NP_113895.1  homer protein homolog 1

      See identical proteins and their annotated locations for NP_113895.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      O08567, O88800, Q9QUJ8, Q9QWN5, Q9Z214
      UniProtKB/TrEMBL
      A0A0H2UI35, A6I4T1
      Related
      ENSRNOP00000086769.2, ENSRNOT00000095790.2
      Conserved Domains (2) summary
      COG1196
      Location:187364
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01206
      Location:3111
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      26279012..26388279
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231775.5XP_006231837.1  homer protein homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_006231837.1

      UniProtKB/TrEMBL
      A0A0H2UI35, A6I4T3
      Conserved Domains (3) summary
      cd01206
      Location:3111
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
      cl12013
      Location:167333
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl19219
      Location:248318
      DUF342; Protein of unknown function (DUF342)
    2. XM_039102105.2XP_038958033.1  homer protein homolog 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZMY0, A6I4U0, A6I4U1
      Related
      ENSRNOP00000079557.2, ENSRNOT00000104734.2
      Conserved Domains (1) summary
      cd01206
      Location:3111
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain