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    gria2b glutamate receptor, ionotropic, AMPA 2b [ Danio rerio (zebrafish) ]

    Gene ID: 170451, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gria2bprovided by ZNC
    Official Full Name
    glutamate receptor, ionotropic, AMPA 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020125-4
    See related
    Ensembl:ENSDARG00000052765 AllianceGenome:ZFIN:ZDB-GENE-020125-4
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    glur2b; gria2.2; zfGRIA2[b]
    Summary
    Predicted to enable AMPA glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and modulation of chemical synaptic transmission. Predicted to act upstream of or within monoatomic ion transmembrane transport. Predicted to be located in postsynaptic membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in dendritic spine and postsynaptic density membrane. Is expressed in central nervous system; retinal neural layer; and sensory neurons. Orthologous to human GRIA2 (glutamate ionotropic receptor AMPA type subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See gria2b in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (35748382..35812827)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (35408024..35473308)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L18 Neighboring gene platelet derived growth factor c Neighboring gene glycine receptor, beta b Neighboring gene transmembrane protein 144b Neighboring gene golgi associated kinase 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Habenula as the experience-dependent controlling switchboard of behavior and attention in social conflict and learning. Okamoto H, et al. Curr Opin Neurobiol, 2021 Jun. PMID 33421772
    2. Ultrastructural analysis of the glutamatergic system in the outer plexiform layer of zebrafish retina. Klooster J, et al. J Chem Neuroanat, 2009 Jul. PMID 19481010
    3. Development and Molecular Investigation into the Effects of Carbamazepine Exposure in the Zebrafish (Danio rerio). Chen H, et al. Int J Environ Res Public Health, 2020 Nov 29. PMID 33260372, Free PMC Article
    4. PKCgamma-induced trafficking of AMPA receptors in embryonic zebrafish depends on NSF and PICK1. Patten SA, et al. Proc Natl Acad Sci U S A, 2009 Apr 21. PMID 19366675, Free PMC Article
    5. Hunger Potentiates the Habenular Winner Pathway for Social Conflict by Orexin-Promoted Biased Alternative Splicing of the AMPA Receptor Gene. Nakajo H, et al. Cell Rep, 2020 Jun 23. PMID 32579920

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables AMPA glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of AMPA glutamate receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glutamate receptor 2b
    Names
    glutamate receptor, ionotropic, AMPA 2.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131895.2 → NP_571970.2  glutamate receptor 2b precursor

      See identical proteins and their annotated locations for NP_571970.2

      Status: PROVISIONAL

      Source sequence(s)
      AF525744
      UniProtKB/TrEMBL
      Q71E62
      Related
      ENSDARP00000064616.4, ENSDART00000064617.6
      Conserved Domains (4) summary
      cd06389
      Location:27 → 395
      PBP1_iGluR_AMPA_GluR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
      cd13715
      Location:410 → 790
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:542 → 820
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:55 → 377
      ANF_receptor; Receptor family ligand binding region

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      35748382..35812827
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005157306.5 → XP_005157363.1  glutamate receptor 2b isoform X3

      UniProtKB/TrEMBL
      A0A140LG34, A0A8M2B3E9
      Related
      ENSDARP00000142212.1, ENSDART00000172803.2
      Conserved Domains (4) summary
      cd06389
      Location:27 → 395
      PBP1_iGluR_AMPA_GluR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
      cd13715
      Location:410 → 790
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:542 → 820
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:55 → 377
      ANF_receptor; Receptor family ligand binding region

    2. XM_005157304.5 → XP_005157361.1  glutamate receptor 2b isoform X1

      UniProtKB/TrEMBL
      A0A8M2B430, F1QKT1
      Related
      ENSDARP00000069157.3, ENSDART00000074671.4
      Conserved Domains (4) summary
      cd06389
      Location:27 → 395
      PBP1_iGluR_AMPA_GluR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
      cd13715
      Location:410 → 790
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:542 → 820
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:55 → 377
      ANF_receptor; Receptor family ligand binding region

    3. XM_005157305.5 → XP_005157362.1  glutamate receptor 2b isoform X2

      UniProtKB/TrEMBL
      A0A286YAM5, A0A8M2B3D3
      Related
      ENSDARP00000144219.2, ENSDART00000177391.2
      Conserved Domains (4) summary
      cd06389
      Location:27 → 395
      PBP1_iGluR_AMPA_GluR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
      cd13715
      Location:410 → 790
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:542 → 820
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:55 → 377
      ANF_receptor; Receptor family ligand binding region

    4. XM_068213151.1 → XP_068069252.1  glutamate receptor 2b isoform X6

    5. XM_068213149.1 → XP_068069250.1  glutamate receptor 2b isoform X4

    6. XM_068213150.1 → XP_068069251.1  glutamate receptor 2b isoform X5

    7. XM_068213152.1 → XP_068069253.1  glutamate receptor 2b isoform X7

    RNA

    1. XR_658190.4 RNA Sequence

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395318.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      296434..341938
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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