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    Api5 apoptosis inhibitor 5 [ Mus musculus (house mouse) ]

    Gene ID: 11800, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Api5provided by MGI
    Official Full Name
    apoptosis inhibitor 5provided by MGI
    Primary source
    MGI:MGI:1888993
    See related
    Ensembl:ENSMUSG00000027193 AllianceGenome:MGI:1888993
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    API-5; AAC-11
    Summary
    Predicted to enable RNA binding activity and fibroblast growth factor binding activity. Acts upstream of or within negative regulation of fibroblast apoptotic process. Part of spliceosomal complex. Is expressed in several structures, including central nervous system and retina. Orthologous to human API5 (apoptosis inhibitor 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 28.3), bladder adult (RPKM 22.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Api5 in Genome Data Viewer
    Location:
    2 E1; 2 51.84 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (94242073..94268490, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (94411727..94438186, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 17 Neighboring gene inosine triphosphatase (nucleoside triphosphate pyrophosphatase) pseudogene 1 Neighboring gene RIKEN cDNA 2810002D19 gene Neighboring gene STARR-positive B cell enhancer mm9_chr2:94278212-94278513 Neighboring gene STARR-positive B cell enhancer mm9_chr2:94306013-94306313 Neighboring gene STARR-seq mESC enhancer starr_05179 Neighboring gene predicted gene 13788 Neighboring gene predicted gene, 24318

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal. Tewari M, et al. Cancer Res, 1997 Sep 15. PMID 9307294
    2. Myb proteins regulate the expression of diverse target genes. Lang G, et al. Oncogene, 2005 Feb 17. PMID 15608679
    3. Identification of genes differentially expressed in vascular smooth muscle cells following benzo[a]pyrene challenge: implications for chemical atherogenesis. Lu KP, et al. Biochem Biophys Res Commun, 1998 Dec 30. PMID 9918813
    4. The γδ IEL effector API5 masks genetic susceptibility to Paneth cell death. Matsuzawa-Ishimoto Y, et al. Nature, 2022 Oct. PMID 36198790, Free PMC Article
    5. Maternal diabetes alters transcriptional programs in the developing embryo. Pavlinkova G, et al. BMC Genomics, 2009 Jun 18. PMID 19538749, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The gammadelta IEL effector API5 masks genetic susceptibility to Paneth cell death.
      Title: The γδ IEL effector API5 masks genetic susceptibility to Paneth cell death.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fibroblast growth factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fibroblast growth factor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of fibroblast apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of fibroblast apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    apoptosis inhibitor 5
    Names
    apoptosis inhibitory protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305258.2 → NP_001292187.1  apoptosis inhibitor 5 isoform 1

      See identical proteins and their annotated locations for NP_001292187.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL672251
      UniProtKB/TrEMBL
      Q3UYQ4
      Conserved Domains (3) summary
      pfam05918
      Location:4 → 495
      API5; Apoptosis inhibitory protein 5 (API5)
      pfam13646
      Location:70 → 156
      HEAT_2; HEAT repeats
      sd00044
      Location:63 → 91
      HEAT; HEAT repeat [structural motif]

    2. NM_001349003.2 → NP_001335932.1  apoptosis inhibitor 5 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL672251
      Conserved Domains (2) summary
      sd00044
      Location:63 → 91
      HEAT; HEAT repeat [structural motif]
      pfam05918
      Location:4 → 504
      API5; Apoptosis inhibitory protein 5 (API5)

    3. NM_007466.4 → NP_031492.2  apoptosis inhibitor 5 isoform 2

      See identical proteins and their annotated locations for NP_031492.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and uses an alternate splice site in the 3' coding region that results in a frame-shift compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL672251
      Consensus CDS
      CCDS16459.1
      UniProtKB/Swiss-Prot
      O35841, Q3U517, Q922L2
      Related
      ENSMUSP00000028617.7, ENSMUST00000028617.7
      Conserved Domains (3) summary
      pfam05918
      Location:4 → 495
      API5; Apoptosis inhibitory protein 5 (API5)
      pfam13646
      Location:70 → 156
      HEAT_2; HEAT repeats
      sd00044
      Location:63 → 91
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      94242073..94268490 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35841.2 GenPept UniProtKB/Swiss-Prot:O35841

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