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    Ints15 integrator complex subunit 15 [ Mus musculus (house mouse) ]

    Gene ID: 231868, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ints15provided by MGI
    Official Full Name
    integrator complex subunit 15provided by MGI
    Primary source
    MGI:MGI:2442621
    See related
    Ensembl:ENSMUSG00000039244 AllianceGenome:MGI:2442621
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ents15; A630028N22; E130309D02Rik
    Summary
    Predicted to be part of integrator complex. Is expressed in several structures, including alimentary system; central nervous system; ganglia; sensory organ; and submandibular gland primordium. Orthologous to human INTS15 (integrator complex subunit 15). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 23.4), thymus adult (RPKM 22.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ints15 in Genome Data Viewer
    Location:
    5 G2; 5 82.07 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (143286827..143301147, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (143301072..143315387, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 853 Neighboring gene predicted gene, 52794 Neighboring gene zinc finger, DHHC domain containing 4 Neighboring gene RIKEN cDNA 0610040B10 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Integrator complex subunit 15 controls mRNA splicing and is critical for eye development. Azuma N, et al. Hum Mol Genet, 2023 Jun 5. PMID 36851842
    2. Single-cell architecture and functional requirement of alternative splicing during hematopoietic stem cell formation. Wang F, et al. Sci Adv, 2022 Jan 7. PMID 34995116, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Integrator complex subunit 15 controls mRNA splicing and is critical for eye development.
      Title: Integrator complex subunit 15 controls mRNA splicing and is critical for eye development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of integrator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    integrator complex subunit 15
    Names
    uncharacterized protein C7orf26 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172726.4 → NP_766314.3  integrator complex subunit 15

      See identical proteins and their annotated locations for NP_766314.3

      Status: VALIDATED

      Source sequence(s)
      AK053801, CJ315714
      Consensus CDS
      CCDS19839.1
      UniProtKB/Swiss-Prot
      Q3T9D0, Q8BGA7, Q8BN55
      Related
      ENSMUSP00000041800.3, ENSMUST00000046418.3
      Conserved Domains (1) summary
      pfam14964
      Location:2 → 380
      DUF4507; Domain of unknown function (DUF4507)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      143286827..143301147 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504697.3 → XP_006504760.1  integrator complex subunit 15 isoform X1

      Conserved Domains (1) summary
      pfam14964
      Location:1 → 303
      DUF4507; Domain of unknown function (DUF4507)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGA7.1 GenPept UniProtKB/Swiss-Prot:Q8BGA7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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