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    dhx57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 [ Danio rerio (zebrafish) ]

    Gene ID: 555250, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dhx57provided by ZNC
    Official Full Name
    DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-4078
    See related
    Ensembl:ENSDARG00000057660 AllianceGenome:ZFIN:ZDB-GENE-030131-4078
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc68d07; wu:fc68d07; si:ch211-250c4.7
    Summary
    Predicted to enable RNA binding activity and helicase activity. Predicted to be located in membrane. Orthologous to human DHX57 (DExH-box helicase 57). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See dhx57 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (8320450..8353504, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (7988647..8021484, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain 110 molecular ruler complex subunit Neighboring gene atlastin GTPase 2 Neighboring gene galactose mutarotase Neighboring gene endothelial PAS domain protein 1b Neighboring gene protein kinase C, epsilon b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Pla2g6 Deficiency in Zebrafish Leads to Dopaminergic Cell Death, Axonal Degeneration, Increased β-Synuclein Expression, and Defects in Brain Functions and Pathways. Sánchez E, et al. Mol Neurobiol, 2018 Aug. PMID 29344929
    2. Transcriptomic analyses reveal novel genes with sexually dimorphic expression in the zebrafish gonad and brain. Sreenivasan R, et al. PLoS One, 2008 Mar 12. PMID 18335061, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative ATP-dependent RNA helicase DHX57
    XP_001921063.3
    XP_021328300.1
    XP_021328305.1
    XP_021336395.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      8320450..8353504 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021480720.2 → XP_021336395.1  putative ATP-dependent RNA helicase DHX57 isoform X1

      UniProtKB/TrEMBL
      A0A8M9QNL6, F1QCB1
      Related
      ENSDARP00000074801.4, ENSDART00000080351.6
      Conserved Domains (3) summary
      COG1643
      Location:537 → 1419
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      COG5175
      Location:309 → 510
      MOT2; Transcriptional repressor [Transcription]
      cl21463
      Location:198 → 239
      UBA_like_SF; UBA domain-like superfamily

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394863.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      348748..362321 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021472625.2 → XP_021328300.1  putative ATP-dependent RNA helicase DHX57 isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q4T8
      Conserved Domains (1) summary
      COG1643
      Location:10 → 504
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394864.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      507..14150 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021472630.2 → XP_021328305.1  putative ATP-dependent RNA helicase DHX57 isoform X3

      UniProtKB/TrEMBL
      A0A8M9Q4U2
      Conserved Domains (3) summary
      COG1643
      Location:537 → 801
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      COG5175
      Location:309 → 510
      MOT2; Transcriptional repressor [Transcription]
      cl21463
      Location:198 → 239
      UBA_like_SF; UBA domain-like superfamily

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395305.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      164864..197936 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001921028.6 → XP_001921063.3  putative ATP-dependent RNA helicase DHX57 isoform X1

      UniProtKB/TrEMBL
      A0A2R8Q3V8, A0A8M1QHI5
      Conserved Domains (3) summary
      COG1643
      Location:538 → 1420
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      COG5175
      Location:310 → 511
      MOT2; Transcriptional repressor [Transcription]
      cl21463
      Location:199 → 240
      UBA_like_SF; UBA domain-like superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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