trpa1a transient receptor potential cation channel, subfamily A, member 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: trpa1aprovided by ZNC
Official Full Name: transient receptor potential cation channel, subfamily A, member 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050105-6
See related: Ensembl:ENSDARG00000016699 AllianceGenome:ZFIN:ZDB-GENE-050105-6
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: trpa1; ANKTM1
Summary: Enables intracellularly gated calcium channel activity and mechanosensitive monoatomic ion channel activity. Acts upstream of or within detection of chemical stimulus; detection of mechanical stimulus involved in sensory perception; and monoatomic ion transmembrane transport. Predicted to be located in membrane. Is expressed in integument; keratinocyte; vagal ganglion; and vagal ganglion 4. Human ortholog(s) of this gene implicated in familial episodic pain syndrome 1. Orthologous to human TRPA1 (transient receptor potential cation channel subfamily A member 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 2

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (30116486..30135446, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (30132953..30151913, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The conducting state of TRPA1 modulates channel lateral mobility.
Title: The conducting state of TRPA1 modulates channel lateral mobility.
Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways.
Title: Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways.
A critical evaluation of TRPA1-mediated locomotor behavior in zebrafish as a screening tool for novel anti-nociceptive drug discovery.
Title: A critical evaluation of TRPA1-mediated locomotor behavior in zebrafish as a screening tool for novel anti-nociceptive drug discovery.
These findings provide novel insights into the structure-function relationship of TRPA1 and could lead to the development of more effective analgesics targeted to TRPA1.
Title: Structural basis of TRPA1 inhibition by HC-030031 utilizing species-specific differences.
Zebrafish TRPA1a is specialized for chemical sensing, whereas zTRPA1b responds to thermal stimuli.
Title: Sensitivities of Two Zebrafish TRPA1 Paralogs to Chemical and Thermal Stimuli Analyzed in Heterologous Expression Systems.
Larvae heterozygous for mutations in trpa1a respond to mustard oil to an extent similar to that of their wild-type siblings.
Title: Zebrafish TRPA1 channels are required for chemosensation but not for thermosensation or mechanosensory hair cell function.
Inhibition of TRPA1 protein expression in zebrafish and mouse inner ears inhibits receptor cell function
Title: TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables intracellularly gated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables ligand-gated monoatomic ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables mechanosensitive monoatomic ion channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within detection of chemical stimulus	IDA Inferred from Direct Assay more info	PubMed
NOT acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception	IMP Inferred from Mutant Phenotype more info	PubMed
NOT acts_upstream_of_or_within detection of temperature stimulus involved in thermoception	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within monoatomic ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
NOT acts_upstream_of_or_within response to fatty acid	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: transient receptor potential cation channel subfamily A member 1a

Names: transient receptor potential cation channel subfamily A member 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007065.1 → NP_001007066.1 transient receptor potential cation channel subfamily A member 1a

See identical proteins and their annotated locations for NP_001007066.1

Status: PROVISIONAL

Source sequence(s)

AY677196

UniProtKB/TrEMBL

Q5UM15

Related

ENSDARP00000119200.1, ENSDART00000141906.2

Conserved Domains (5) summary

cd00204
Location:474 → 598

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam00520
Location:784 → 963

Ion_trans; Ion transport protein

pfam12796
Location:241 → 337

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:199 → 255

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:480 → 509

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007113.7 Reference GRCz11 Primary Assembly

Range

30116486..30135446 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017358267.3 → XP_017213756.1 transient receptor potential cation channel subfamily A member 1a isoform X1

UniProtKB/TrEMBL

A0A8M6Z942

Conserved Domains (5) summary

cd00204
Location:474 → 598

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam00520
Location:784 → 963

Ion_trans; Ion transport protein

pfam12796
Location:241 → 337

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:199 → 255

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:480 → 509

ANK; ANK repeat [structural motif]