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    greb1l GREB1 like retinoic acid receptor coactivator [ Danio rerio (zebrafish) ]

    Gene ID: 100005373, updated on 4-Jan-2025

    Summary

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    Official Symbol
    greb1lprovided by ZNC
    Official Full Name
    GREB1 like retinoic acid receptor coactivatorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-4022
    See related
    Ensembl:ENSDARG00000039196 AllianceGenome:ZFIN:ZDB-GENE-030131-4022
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc65f09; wu:fc55e03; wu:fc65f09; si:dkey-203o21.1; si:dkey-264l15.1
    Summary
    Involved in kidney development. Acts upstream of or within pronephros development. Predicted to be located in membrane. Is expressed in central nervous system and mesoderm. Used to study renal agenesis. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 80 and renal agenesis. Orthologous to human GREB1L (GREB1 like retinoic acid receptor coactivator). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See greb1l in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (11685808..11833278)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (11902197..12049680)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene mitochondrial fission factor b Neighboring gene finTRIM family, member 1 Neighboring gene abhydrolase domain containing 3, phospholipase Neighboring gene Ro60, Y RNA binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A Gene Implicated in Activation of Retinoic Acid Receptor Targets Is a Novel Renal Agenesis Gene in Humans. Brophy PD, et al. Genetics, 2017 Sep. PMID 28739660, Free PMC Article
    2. Exome-wide Association Study Identifies GREB1L Mutations in Congenital Kidney Malformations. Sanna-Cherchi S, et al. Am J Hum Genet, 2017 Nov 2. PMID 29100090, Free PMC Article
    3. SpG and SpRY variants expand the CRISPR toolbox for genome editing in zebrafish. Liang F, et al. Nat Commun, 2022 Jun 14. PMID 35701400, Free PMC Article
    4. Transcriptional profiling of angiogenesis activities of calycosin in zebrafish. Li S, et al. Mol Biosyst, 2011 Nov. PMID 21909574
    5. Genomewide expression profiling in the zebrafish embryo identifies target genes regulated by Hedgehog signaling during vertebrate development. Xu J, et al. Genetics, 2006 Oct. PMID 16888327, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0575

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in kidney development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in kidney development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in morphogenesis of an epithelium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within pronephros development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GREB1-like protein
    Names
    growth regulation by estrogen in breast cancer-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362307.1 → NP_001349236.1  GREB1-like protein

      Status: VALIDATED

      Source sequence(s)
      CT573467, CU138514, CU682364
      UniProtKB/Swiss-Prot
      B8JKP6, F1QLH8
      UniProtKB/TrEMBL
      A0A8M9NZP6
      Conserved Domains (1) summary
      pfam15782
      Location:1 → 1942
      GREB1; Gene regulated by oestrogen in breast cancer

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      11685808..11833278
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009298040.3 → XP_009296315.1  GREB1-like protein isoform X1

      See identical proteins and their annotated locations for XP_009296315.1

      UniProtKB/Swiss-Prot
      B8JKP6, F1QLH8
      UniProtKB/TrEMBL
      A0A8M9NZP6
      Related
      ENSDARP00000122959.2, ENSDART00000138562.4
      Conserved Domains (1) summary
      pfam15782
      Location:1 → 1942
      GREB1; Gene regulated by oestrogen in breast cancer

    2. XM_068222368.1 → XP_068078469.1  GREB1-like protein isoform X1

      UniProtKB/Swiss-Prot
      B8JKP6, F1QLH8
      UniProtKB/TrEMBL
      A0A8M9NZP6

    3. XM_021466912.2 → XP_021322587.1  GREB1-like protein isoform X1

      UniProtKB/Swiss-Prot
      B8JKP6, F1QLH8
      UniProtKB/TrEMBL
      A0A8M9NZP6
      Conserved Domains (1) summary
      pfam15782
      Location:1 → 1942
      GREB1; Gene regulated by oestrogen in breast cancer
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B8JKP6.2 GenPept UniProtKB/Swiss-Prot:B8JKP6

    Gene LinkOut

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