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    Suds3 suppressor of defective silencing 3 homolog (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 71954, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Suds3provided by MGI
    Official Full Name
    suppressor of defective silencing 3 homolog (S. cerevisiae)provided by MGI
    Primary source
    MGI:MGI:1919204
    See related
    Ensembl:ENSMUSG00000066900 AllianceGenome:MGI:1919204
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mSds3; 2400003N08Rik; 2410008L21Rik
    Summary
    Enables histone deacetylase binding activity and identical protein binding activity. Involved in negative regulation of DNA-templated transcription. Acts upstream of or within blastocyst hatching. Part of Sin3-type complex. Is expressed in early conceptus; ovary; secondary oocyte; and seminiferous cord. Orthologous to human SUDS3 (SDS3 homolog, SIN3A corepressor complex component). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 43.8), ovary adult (RPKM 42.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Suds3 in Genome Data Viewer
    Location:
    5 F; 5 56.88 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (117229743..117257980, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (117091678..117115993, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 7478 Neighboring gene predicted gene, 42011 Neighboring gene STARR-positive B cell enhancer ABC_E3606 Neighboring gene STARR-positive B cell enhancer ABC_E2172 Neighboring gene STARR-seq mESC enhancer starr_14168 Neighboring gene STARR-positive B cell enhancer ABC_E6369 Neighboring gene TAO kinase 3 Neighboring gene STARR-positive B cell enhancer ABC_E3607 Neighboring gene STARR-positive B cell enhancer ABC_E3608 Neighboring gene STARR-positive B cell enhancer ABC_E3609 Neighboring gene STARR-seq mESC enhancer starr_14169 Neighboring gene STARR-positive B cell enhancer ABC_E8074 Neighboring gene phosphatidylethanolamine binding protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SDS3 regulates microglial inflammation by modulating the expression of the upstream kinase ASK1 in the p38 MAPK signaling pathway. Shen J, et al. Inflamm Res, 2024 Sep. PMID 39008037, Free PMC Article
    2. Haploinsufficiency of the mSds3 chromatin regulator promotes chromosomal instability and cancer only upon complete neutralization of p53. David G, et al. Oncogene, 2006 Nov 30. PMID 16767157
    3. mSin3-associated protein, mSds3, is essential for pericentric heterochromatin formation and chromosome segregation in mammalian cells. David G, et al. Genes Dev, 2003 Oct 1. PMID 14522945, Free PMC Article
    4. Depletion of Suds3 reveals an essential role in early lineage specification. Zhang K, et al. Dev Biol, 2013 Jan 15. PMID 23123966
    5. Cdk5 phosphorylates a component of the HDAC complex and regulates histone acetylation during neuronal cell death. Fu AK, et al. Neurosignals, 2013. PMID 22398430

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SDS3 regulates microglial inflammation by modulating the expression of the upstream kinase ASK1 in the p38 MAPK signaling pathway.
      Title: SDS3 regulates microglial inflammation by modulating the expression of the upstream kinase ASK1 in the p38 MAPK signaling pathway.
    2. These data define a role for Suds3 in activation of FGF4/ERK signaling.
      Title: Depletion of Suds3 reveals an essential role in early lineage specification.
    3. the identification of Sds3 (suppressor of defective silencing 3) as an adaptor protein that recruits the Sin3 [SWI (switch)-independent 3]-HDAC (histone deacetylase) repression complex and binds Foxk1.
      Title: Foxk1 recruits the Sds3 complex and represses gene expression in myogenic progenitors.
    4. capacity of mSds3 to cooperate with p53 deficiency in cancer predisposition relates to its specific role in chromosome segregation, rather than its central role in maintaining a functional mSin3A complex
      Title: Haploinsufficiency of the mSds3 chromatin regulator promotes chromosomal instability and cancer only upon complete neutralization of p53.
    5. mSds3 and its associated mSin3/HDAC components play a central role in initiating the cascade of pericentric heterochromatin-specific modifications necessary for the proper distribution of chromosomes during cell division in mammalian cells.
      Title: mSin3-associated protein, mSds3, is essential for pericentric heterochromatin formation and chromosome segregation in mammalian cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to histone deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to histone deacetylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone deacetylase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within blastocyst hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cell migration NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of stem cell population maintenance NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of stem cell population maintenance NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Sin3-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Sin3-type complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Sin3-type complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sin3 histone deacetylase corepressor complex component SDS3
    Names
    suppressor of defective silencing 3 protein homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122666.2 → NP_001116138.1  sin3 histone deacetylase corepressor complex component SDS3 isoform b

      See identical proteins and their annotated locations for NP_001116138.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the shorter transcript and encodes the longer isoform (b).
      Source sequence(s)
      AV338433, BC055764, BC062176, CJ094124
      Consensus CDS
      CCDS51631.1
      UniProtKB/TrEMBL
      A0A0R4J243
      Related
      ENSMUSP00000130535.2, ENSMUST00000166397.3
      Conserved Domains (1) summary
      pfam08598
      Location:62 → 178
      Sds3; Sds3-like

    2. NM_178622.5 → NP_848737.3  sin3 histone deacetylase corepressor complex component SDS3 isoform a

      See identical proteins and their annotated locations for NP_848737.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 3' coding region and the 3' UTR, compared to variant 2. It encodes isoform a, which has a shorter and distinct C-terminus, compared to isoform b.
      Source sequence(s)
      AV338433, BC055764, CJ094124
      Consensus CDS
      CCDS39232.1
      UniProtKB/Swiss-Prot
      Q3UC92, Q6P6K1, Q7TNT0, Q8BR65, Q8BRR7, Q8K5B4
      Related
      ENSMUSP00000083662.6, ENSMUST00000086471.12
      Conserved Domains (1) summary
      pfam08598
      Location:62 → 178
      Sds3; Sds3-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      117229743..117257980 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165504.1 → XP_036021397.1  sin3 histone deacetylase corepressor complex component SDS3 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BR65.1 GenPept UniProtKB/Swiss-Prot:Q8BR65

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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