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    Cckbr cholecystokinin B receptor [ Mus musculus (house mouse) ]

    Gene ID: 12426, updated on 3-Dec-2024

    Summary

    Official Symbol
    Cckbrprovided by MGI
    Official Full Name
    cholecystokinin B receptorprovided by MGI
    Primary source
    MGI:MGI:99479
    See related
    Ensembl:ENSMUSG00000030898 AllianceGenome:MGI:99479
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CCK2R; CCK-BR; CCK2-R; CCKR-2
    Summary
    This gene encodes a multipass transmembrane receptor protein expressed in the central nervous system and gastrointestinal tract. Cholecystokinin and gastrin bind to the encoded protein to stimulate gastric acid secretion and mucosal growth in the gastrointestinal tract, and anxiety, pain sensation and memory in the brain. Mice lacking the encoded protein exhibit an increase in the basal gastric pH and gastrin levels in the bloodstream as well as mild hypocalcemia, secondary hyperparathyroidism and increased bone resorption. [provided by RefSeq, Apr 2015]
    Expression
    Biased expression in cortex adult (RPKM 23.1), frontal lobe adult (RPKM 18.4) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Cckbr in Genome Data Viewer
    Location:
    7 E3; 7 55.86 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (105075201..105085546)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (105425676..105436339)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene FHF complex subunit HOOK interacting protein 1B Neighboring gene STARR-positive B cell enhancer ABC_E3739 Neighboring gene cyclic nucleotide gated channel alpha 4 Neighboring gene predicted gene 4972 Neighboring gene STARR-seq mESC enhancer starr_19745 Neighboring gene STARR-seq mESC enhancer starr_19746 Neighboring gene caveolae associated 3 Neighboring gene predicted gene, 36847

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cholecystokinin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cholecystokinin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables gastrin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables gastrin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables gastrin receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables neuropeptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptide hormone binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables type B gastrin/cholecystokinin receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables type B gastrin/cholecystokinin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in behavioral defense response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cholecystokinin signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within digestive tract development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in estrous cycle ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within gastric acid secretion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within gastric acid secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in histamine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within pH reduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of behavioral fear response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of somatostatin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of synaptic transmission, GABAergic ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    gastrin/cholecystokinin type B receptor
    Names
    CCK-B receptor
    CCK-B/gastrin receptor
    CCK2/gastrin receptor
    cholecystokinin-2 receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001412224.1NP_001399153.1  gastrin/cholecystokinin type B receptor isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC125055
      UniProtKB/TrEMBL
      Q8BKF6
    2. NM_007627.6NP_031653.1  gastrin/cholecystokinin type B receptor isoform 1

      See identical proteins and their annotated locations for NP_031653.1

      Status: REVIEWED

      Source sequence(s)
      AC125055
      Consensus CDS
      CCDS21651.1
      UniProtKB/Swiss-Prot
      P56481
      UniProtKB/TrEMBL
      Q3ZB46, Q8BKF6
      Related
      ENSMUSP00000033189.4, ENSMUST00000033189.6
      Conserved Domains (2) summary
      pfam00001
      Location:71396
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:60191
      7tm_4; Olfactory receptor

    RNA

    1. NR_178082.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC125055

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      105075201..105085546
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)