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    Cyb5r3 cytochrome b5 reductase 3 [ Mus musculus (house mouse) ]

    Gene ID: 109754, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cyb5r3provided by MGI
    Official Full Name
    cytochrome b5 reductase 3provided by MGI
    Primary source
    MGI:MGI:94893
    See related
    Ensembl:ENSMUSG00000018042 AllianceGenome:MGI:94893
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B5R; Dia1; Dia-1; WU:Cyb5r3; 0610016L08Rik; 2500002N19Rik
    Summary
    Predicted to enable cytochrome-b5 reductase activity, acting on NAD(P)H and nucleotide binding activity. Predicted to contribute to nitrite reductase (NO-forming) activity. Predicted to be involved in nitric oxide biosynthetic process. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in breast cancer and methemoglobinemia. Orthologous to human CYB5R3 (cytochrome b5 reductase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in duodenum adult (RPKM 409.4), adrenal adult (RPKM 270.7) and 23 other tissues See more
    Orthologs
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    Genomic context

    See Cyb5r3 in Genome Data Viewer
    Location:
    15 E1; 15 39.4 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (83037696..83060641, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (83153495..83176440, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene polymerase (DNA-directed), delta interacting protein 3 Neighboring gene RNA U12, small nuclear Neighboring gene STARR-positive B cell enhancer ABC_E4142 Neighboring gene STARR-seq mESC enhancer starr_39316 Neighboring gene STARR-seq mESC enhancer starr_39317 Neighboring gene alpha 1,4-galactosyltransferase Neighboring gene STARR-seq mESC enhancer starr_39321 Neighboring gene STARR-positive B cell enhancer ABC_E5503 Neighboring gene predicted gene, 32886

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ADP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables AMP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables FAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables FAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables FAD binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables NAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytochrome-b5 reductase activity, acting on NAD(P)H ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytochrome-b5 reductase activity, acting on NAD(P)H ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables flavin adenine dinucleotide binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to nitrite reductase (NO-forming) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cholesterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of nitric-oxide synthase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    NADH-cytochrome b5 reductase 3
    Names
    diaphorase 1 (NADH)
    NP_084063.1
    XP_006520345.2
    XP_006520346.1
    XP_030104133.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029787.3NP_084063.1  NADH-cytochrome b5 reductase 3

      See identical proteins and their annotated locations for NP_084063.1

      Status: VALIDATED

      Source sequence(s)
      AI839369, BC043074
      Consensus CDS
      CCDS27698.1
      UniProtKB/Swiss-Prot
      Q9DCN2
      Related
      ENSMUSP00000018186.10, ENSMUST00000018186.16
      Conserved Domains (1) summary
      PLN02252
      Location:14301
      PLN02252; nitrate reductase [NADPH]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      83037696..83060641 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248273.1XP_030104133.1  NADH-cytochrome b5 reductase 3 isoform X2

      UniProtKB/Swiss-Prot
      Q9DCN2
      Conserved Domains (1) summary
      PLN02252
      Location:14301
      PLN02252; nitrate reductase [NADPH]
    2. XM_006520282.3XP_006520345.2  NADH-cytochrome b5 reductase 3 isoform X1

      Conserved Domains (1) summary
      PLN02252
      Location:33320
      PLN02252; nitrate reductase [NADPH]
    3. XM_006520283.5XP_006520346.1  NADH-cytochrome b5 reductase 3 isoform X3

      UniProtKB/Swiss-Prot
      Q9DCN2
      Related
      ENSMUSP00000124062.3, ENSMUST00000162834.3
      Conserved Domains (1) summary
      PLN02252
      Location:15278
      PLN02252; nitrate reductase [NADPH]