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    Mtfr1l mitochondrial fission regulator 1-like [ Mus musculus (house mouse) ]

    Gene ID: 76824, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mtfr1lprovided by MGI
    Official Full Name
    mitochondrial fission regulator 1-likeprovided by MGI
    Primary source
    MGI:MGI:1924074
    See related
    Ensembl:ENSMUSG00000046671 AllianceGenome:MGI:1924074
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam54b; 2410166I05Rik
    Summary
    Predicted to be involved in aerobic respiration and mitochondrial fission. Predicted to be located in mitochondrial outer membrane. Predicted to be active in mitochondrion. Orthologous to human MTFR1L (mitochondrial fission regulator 1 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 60.2), heart adult (RPKM 44.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mtfr1l in Genome Data Viewer
    Location:
    4 D3; 4 66.83 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (134252866..134262698, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (134525555..134535387, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4680 Neighboring gene progestin and adipoQ receptor family member VII Neighboring gene aurora kinase A and ninein interacting protein Neighboring gene STARR-positive B cell enhancer mm9_chr4:134091101-134091402 Neighboring gene selenoprotein N Neighboring gene mannosidase, alpha, class 1C, member 1 Neighboring gene microRNA 6403

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A generic approach for the purification of signaling complexes that specifically interact with the carboxyl-terminal domain of G protein-coupled receptors. Maurice P, et al. Mol Cell Proteomics, 2008 Aug. PMID 18448421, Free PMC Article
    2. Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy. McLelland GL, et al. Elife, 2018 Apr 20. PMID 29676259, Free PMC Article
    3. Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons. Benleulmi-Chaachoua A, et al. J Pineal Res, 2016 Jan. PMID 26514267
    4. The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes. Liu F, et al. Mol Cell Proteomics, 2018 Feb. PMID 29222160, Free PMC Article
    5. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in aerobic respiration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial fission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial fission regulator 1-like
    Names
    family with sequence similarity 54, member B
    protein FAM54B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256112.1 → NP_001243041.1  mitochondrial fission regulator 1-like

      See identical proteins and their annotated locations for NP_001243041.1

      Status: VALIDATED

      Source sequence(s)
      AI836704, AK145362, BY094859
      Consensus CDS
      CCDS18775.1
      UniProtKB/Swiss-Prot
      Q3UJK3, Q8BTP7, Q9CWE0
      UniProtKB/TrEMBL
      D3YW54
      Related
      ENSMUSP00000099609.4, ENSMUST00000102550.10
      Conserved Domains (1) summary
      pfam05308
      Location:9 → 250
      Mito_fiss_reg; Mitochondrial fission regulator

    2. NM_001355187.1 → NP_001342116.1  mitochondrial fission regulator 1-like

      Status: VALIDATED

      Source sequence(s)
      AI836704, AK169047, BY295153
      Consensus CDS
      CCDS18775.1
      UniProtKB/Swiss-Prot
      Q3UJK3, Q8BTP7, Q9CWE0
      UniProtKB/TrEMBL
      D3YW54
      Conserved Domains (1) summary
      pfam05308
      Location:9 → 250
      Mito_fiss_reg; Mitochondrial fission regulator

    3. NM_001355188.1 → NP_001342117.1  mitochondrial fission regulator 1-like

      Status: VALIDATED

      Source sequence(s)
      AI836704, AK169047, AL669982, BY261234, CX200239
      Consensus CDS
      CCDS18775.1
      UniProtKB/Swiss-Prot
      Q3UJK3, Q8BTP7, Q9CWE0
      UniProtKB/TrEMBL
      D3YW54
      Conserved Domains (1) summary
      pfam05308
      Location:9 → 250
      Mito_fiss_reg; Mitochondrial fission regulator

    4. NM_029759.4 → NP_084035.1  mitochondrial fission regulator 1-like

      See identical proteins and their annotated locations for NP_084035.1

      Status: VALIDATED

      Source sequence(s)
      AI836704, AK169047, BY123213
      Consensus CDS
      CCDS18775.1
      UniProtKB/Swiss-Prot
      Q3UJK3, Q8BTP7, Q9CWE0
      UniProtKB/TrEMBL
      D3YW54
      Related
      ENSMUSP00000111983.4, ENSMUST00000116279.10
      Conserved Domains (1) summary
      pfam05308
      Location:9 → 250
      Mito_fiss_reg; Mitochondrial fission regulator

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      134252866..134262698 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539256.2 → XP_006539319.1  mitochondrial fission regulator 1-like isoform X1

      See identical proteins and their annotated locations for XP_006539319.1

      UniProtKB/Swiss-Prot
      Q3UJK3, Q8BTP7, Q9CWE0
      UniProtKB/TrEMBL
      D3YW54
      Related
      ENSMUSP00000117943.2, ENSMUST00000154769.8
      Conserved Domains (1) summary
      pfam05308
      Location:9 → 250
      Mito_fiss_reg; Mitochondrial fission regulator

    2. XM_006539258.3 → XP_006539321.1  mitochondrial fission regulator 1-like isoform X1

      See identical proteins and their annotated locations for XP_006539321.1

      UniProtKB/Swiss-Prot
      Q3UJK3, Q8BTP7, Q9CWE0
      UniProtKB/TrEMBL
      D3YW54
      Conserved Domains (1) summary
      pfam05308
      Location:9 → 250
      Mito_fiss_reg; Mitochondrial fission regulator
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CWE0.1 GenPept UniProtKB/Swiss-Prot:Q9CWE0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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