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    Coq8b coenzyme Q8B [ Mus musculus (house mouse) ]

    Gene ID: 76889, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Coq8bprovided by MGI
    Official Full Name
    coenzyme Q8Bprovided by MGI
    Primary source
    MGI:MGI:1924139
    See related
    Ensembl:ENSMUSG00000003762 AllianceGenome:MGI:1924139
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Adck4; 0610012P18Rik
    Summary
    Predicted to enable ATP binding activity. Predicted to be involved in cerebellar Purkinje cell layer morphogenesis and ubiquinone biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and spinal cord. Human ortholog(s) of this gene implicated in nephrotic syndrome type 9. Orthologous to human COQ8B (coenzyme Q8B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 18.8), ovary adult (RPKM 9.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Coq8b in Genome Data Viewer
    Location:
    7 A3; 7 15.85 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (26928112..26957374)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (27228676..27257949)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene actin maturation protease Neighboring gene microRNA 1191 Neighboring gene inositol 1,4,5-trisphosphate 3-kinase C Neighboring gene STARR-positive B cell enhancer ABC_E2229 Neighboring gene STARR-positive B cell enhancer ABC_E4906 Neighboring gene numb-like Neighboring gene ribosomal protein L14 pseudogene Neighboring gene STARR-seq mESC enhancer starr_18356 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28101108-28101366 Neighboring gene latent transforming growth factor beta binding protein 4 Neighboring gene STARR-positive B cell enhancer ABC_E4907 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28117793-28117976 Neighboring gene predicted gene, 30543

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ADCK4 Deficiency Destabilizes the Coenzyme Q Complex, Which Is Rescued by 2,4-Dihydroxybenzoic Acid Treatment. Widmeier E, et al. J Am Soc Nephrol, 2020 Jun. PMID 32381600, Free PMC Article
    2. The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development. Xu M, et al. Development, 2021 Apr 15. PMID 33913477
    3. A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain. García-Frigola C, et al. Brain Res Mol Brain Res, 2004 Mar 30. PMID 15010206
    4. Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. Quina LA, et al. J Neurosci, 2009 Nov 11. PMID 19906978, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC101983, MGC102655

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cerebellar Purkinje cell layer morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cerebellar Purkinje cell layer morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ubiquinone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquinone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquinone biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    atypical kinase COQ8B, mitochondrial
    Names
    aarF domain containing kinase 4
    aarF domain-containing protein kinase 4
    coenzyme Q protein 8B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133770.2 → NP_598531.2  atypical kinase COQ8B, mitochondrial

      See identical proteins and their annotated locations for NP_598531.2

      Status: VALIDATED

      Source sequence(s)
      AK002619, AK079366, AK137168, BB770607, BY202506
      Consensus CDS
      CCDS39847.1
      UniProtKB/Swiss-Prot
      Q566J8, Q5XJH7, Q91WT5
      UniProtKB/TrEMBL
      E9QLB8
      Related
      ENSMUSP00000003860.7, ENSMUST00000003860.13
      Conserved Domains (1) summary
      cd13970
      Location:176 → 425
      ABC1_ADCK3; Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      26928112..26957374
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540422.4 → XP_006540485.1  atypical kinase COQ8B, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006540485.1

      UniProtKB/Swiss-Prot
      Q566J8, Q5XJH7, Q91WT5
      UniProtKB/TrEMBL
      E9QLB8
      Conserved Domains (1) summary
      cd13970
      Location:176 → 425
      ABC1_ADCK3; Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3

    2. XM_036153553.1 → XP_036009446.1  atypical kinase COQ8B, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q566J8, Q5XJH7, Q91WT5
      UniProtKB/TrEMBL
      E9QLB8
      Conserved Domains (1) summary
      cd13970
      Location:176 → 425
      ABC1_ADCK3; Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3

    3. XM_011250741.4 → XP_011249043.1  atypical kinase COQ8B, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A0A0R4J1X1
      Related
      ENSMUSP00000123309.2, ENSMUST00000128090.8
      Conserved Domains (1) summary
      cl21453
      Location:176 → 299
      PKc_like; Protein Kinases, catalytic domain

    4. XM_017312382.3 → XP_017167871.1  atypical kinase COQ8B, mitochondrial isoform X2

      Conserved Domains (1) summary
      cd13970
      Location:17 → 266
      ABC1_ADCK3; Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3

    5. XM_006540421.2 → XP_006540484.1  atypical kinase COQ8B, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006540484.1

      UniProtKB/Swiss-Prot
      Q566J8, Q5XJH7, Q91WT5
      UniProtKB/TrEMBL
      E9QLB8
      Related
      ENSMUSP00000104015.4, ENSMUST00000108378.10
      Conserved Domains (1) summary
      cd13970
      Location:176 → 425
      ABC1_ADCK3; Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3

    RNA

    1. XR_391109.2 RNA Sequence

    2. XR_004934204.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q566J8.1 GenPept UniProtKB/Swiss-Prot:Q566J8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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