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    Kctd3 potassium channel tetramerization domain containing 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305055, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kctd3provided by RGD
    Official Full Name
    potassium channel tetramerization domain containing 3provided by RGD
    Primary source
    RGD:1310658
    See related
    EnsemblRapid:ENSRNOG00000002627 AllianceGenome:RGD:1310658
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ren-45
    Summary
    Predicted to be involved in protein homooligomerization. Predicted to be located in plasma membrane. Orthologous to human KCTD3 (potassium channel tetramerization domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 163.4), Kidney (RPKM 125.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kctd3 in Genome Data Viewer
    Location:
    13q26
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (103041488..103080069, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (100510193..100548765, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (107433588..107471843, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene usherin Neighboring gene uncharacterized LOC134481543 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC102548492 Neighboring gene uncharacterized LOC102548648 Neighboring gene transmembrane protein 14C like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Up-regulation of hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) by specific interaction with K+ channel tetramerization domain-containing protein 3 (KCTD3). Cao-Ehlker X, et al. J Biol Chem, 2013 Mar 15. PMID 23382386, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    BTB/POZ domain-containing protein KCTD3
    Names
    potassium channel tetramerisation domain containing 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107199.1 → NP_001100669.1  BTB/POZ domain-containing protein KCTD3

      See identical proteins and their annotated locations for NP_001100669.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473985
      UniProtKB/TrEMBL
      A0A8I6A9V0, A6JGV1
      Related
      ENSRNOP00000003556.8, ENSRNOT00000003556.8
      Conserved Domains (2) summary
      smart00225
      Location:20 → 114
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam02214
      Location:20 → 105
      BTB_2; BTB/POZ domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      103041488..103080069 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090826.2 → XP_038946754.1  BTB/POZ domain-containing protein KCTD3 isoform X1

      UniProtKB/TrEMBL
      D3ZNX0
      Conserved Domains (1) summary
      cl38908
      Location:17 → 119
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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