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    Leo1 LEO1 homolog, Paf1/RNA polymerase II complex component [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300837, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Leo1provided by RGD
    Official Full Name
    LEO1 homolog, Paf1/RNA polymerase II complex componentprovided by RGD
    Primary source
    RGD:1549772
    See related
    EnsemblRapid:ENSRNOG00000010116 AllianceGenome:RGD:1549772
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA polymerase II C-terminal domain phosphoserine binding activity. Predicted to be involved in several processes, including RNA metabolic process; endodermal cell fate commitment; and positive regulation of transcription elongation by RNA polymerase II. Predicted to be located in centrosome; fibrillar center; and nucleoplasm. Predicted to be part of Cdc73/Paf1 complex. Predicted to be active in nucleus. Orthologous to human LEO1 (LEO1 homolog, Paf1/RNA polymerase II complex component). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 78.5), Thymus (RPKM 72.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Leo1 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (85080036..85104471)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (76199547..76223983)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (82380906..82405293)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase 6 Neighboring gene uncharacterized LOC102551227 Neighboring gene RNA polymerase-associated protein LEO1-like Neighboring gene tropomodulin 3 Neighboring gene uncharacterized LOC134480207

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Transcriptional activators enhance polyadenylation of mRNA precursors. Nagaike T, et al. Mol Cell, 2011 Feb 18. PMID 21329879, Free PMC Article
    2. The Paf1 complex: platform or player in RNA polymerase II transcription? Jaehning JA. Biochim Biophys Acta, 2010 May-Jun. PMID 20060942, Free PMC Article
    3. The parafibromin tumor suppressor protein inhibits cell proliferation by repression of the c-myc proto-oncogene. Lin L, et al. Proc Natl Acad Sci U S A, 2008 Nov 11. PMID 18987311, Free PMC Article
    4. The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis. Muntean AG, et al. Cancer Cell, 2010 Jun 15. PMID 20541477, Free PMC Article
    5. The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS. Kim J, et al. Cell, 2010 Feb 19. PMID 20178742, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC95290

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II C-terminal domain phosphoserine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in endodermal cell fate commitment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endodermal cell fate commitment ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mRNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA 3'-end processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of myeloid cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of myeloid cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stem cell population maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transcription elongation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription elongation by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Cdc73/Paf1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cdc73/Paf1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA polymerase-associated protein LEO1
    Names
    Leo1 Paf1/RNA polymerase II complex component

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005548.1 → NP_001005548.1  RNA polymerase-associated protein LEO1

      See identical proteins and their annotated locations for NP_001005548.1

      Status: PROVISIONAL

      Source sequence(s)
      BC082098
      UniProtKB/Swiss-Prot
      Q641X2
      Related
      ENSRNOP00000110799.1, ENSRNOT00000136176.1
      Conserved Domains (2) summary
      PHA02664
      Location:33 → 183
      PHA02664; hypothetical protein; Provisional
      pfam04004
      Location:386 → 544
      Leo1; Leo1-like protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      85080036..85104471
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081146.2 → XP_038937074.1  RNA polymerase-associated protein LEO1 isoform X1

      Conserved Domains (2) summary
      pfam04004
      Location:190 → 352
      Leo1; Leo1-like protein
      NF033845
      Location:6 → 166
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q641X2.1 GenPept UniProtKB/Swiss-Prot:Q641X2

    Gene LinkOut

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