Pafah1b2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pafah1b2provided by RGD
Official Full Name: platelet-activating factor acetylhydrolase 1b, catalytic subunit 2provided by RGD
Primary source: RGD:620332
See related: EnsemblRapid:ENSRNOG00000057102 AllianceGenome:RGD:620332
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables 1-alkyl-2-acetylglycerophosphocholine esterase activity; identical protein binding activity; and platelet-activating factor acetyltransferase activity. Predicted to be involved in positive regulation of macroautophagy and spermatogenesis. Part of 1-alkyl-2-acetylglycerophosphocholine esterase complex. Human ortholog(s) of this gene implicated in lymphoma. Orthologous to human PAFAH1B2 (platelet activating factor acetylhydrolase 1b catalytic subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 343.2), Adrenal (RPKM 234.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (55156778..55208800, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (46260069..46312073, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (50256969..50310043, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MicroRNA-212-5p and its target PAFAH1B2 suppress vascular proliferation and contraction via the downregulation of RhoA.
Title: MicroRNA-212-5p and its target PAFAH1B2 suppress vascular proliferation and contraction via the downregulation of RhoA.
the PAF receptor-independent death pathway is regulated by PAF-AH I alpha2
Title: Anti-apoptotic actions of the platelet-activating factor acetylhydrolase I alpha2 catalytic subunit.

Submit: New GeneRIF Correction

General gene information

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Markers

RH143765 (e-PCR)
- UniSTS:233011

AI228182 (e-PCR)
- UniSTS:261480

RH128517 (e-PCR)
- UniSTS:211825

AI747451 (e-PCR)
- UniSTS:163457

RH141413 (e-PCR)
- UniSTS:223407

D8Got71 (e-PCR)
- UniSTS:114120

Pafah1b2 (e-PCR), detects polymorphism
- UniSTS:144115

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables platelet-activating factor acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables platelet-activating factor acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables platelet-activating factor acetyltransferase activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of macroautophagy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of 1-alkyl-2-acetylglycerophosphocholine esterase complex	IDA Inferred from Direct Assay more info	PubMed
part_of 1-alkyl-2-acetylglycerophosphocholine esterase complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: platelet-activating factor acetylhydrolase IB subunit alpha2

Names: PAF acetylhydrolase 30 kDa subunit; PAF-AH 30 kDa subunit; PAF-AH alpha 2; PAF-AH subunit beta; PAFAH subunit beta; platelet-activating factor acetylhydrolase IB subunit beta; platelet-activating factor acetylhydrolase alpha 2 subunit (PAF-AH alpha 2)

NP_071782.1

EC 3.1.1.47

XP_006243020.1

EC 3.1.1.47

XP_038938009.1

EC 3.1.1.47

XP_038938010.1

EC 3.1.1.47

XP_063122144.1

EC 3.1.1.47

XP_063122145.1

EC 3.1.1.47

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022387.3 → NP_071782.1 platelet-activating factor acetylhydrolase IB subunit alpha2

See identical proteins and their annotated locations for NP_071782.1

Status: PROVISIONAL

Source sequence(s)

BC081714

UniProtKB/Swiss-Prot

O35264

UniProtKB/TrEMBL

A0A8L2R003, A6J468

Related

ENSRNOP00000068672.3, ENSRNOT00000082508.3

Conserved Domains (1) summary

cd01820
Location:8 → 217

PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

55156778..55208800 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006242958.5 → XP_006243020.1 platelet-activating factor acetylhydrolase IB subunit alpha2 isoform X1

See identical proteins and their annotated locations for XP_006243020.1

UniProtKB/Swiss-Prot

O35264

UniProtKB/TrEMBL

A0A8L2R003, A6J468

Conserved Domains (1) summary

cd01820
Location:8 → 217

PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...
XM_039082082.2 → XP_038938010.1 platelet-activating factor acetylhydrolase IB subunit alpha2 isoform X1

UniProtKB/Swiss-Prot

O35264

UniProtKB/TrEMBL

A0A8L2R003, A6J468

Conserved Domains (1) summary

cd01820
Location:8 → 217

PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...
XM_063266075.1 → XP_063122145.1 platelet-activating factor acetylhydrolase IB subunit alpha2 isoform X1

UniProtKB/Swiss-Prot

O35264

UniProtKB/TrEMBL

A0A8L2R003, A6J468
XM_039082081.2 → XP_038938009.1 platelet-activating factor acetylhydrolase IB subunit alpha2 isoform X1

UniProtKB/Swiss-Prot

O35264

UniProtKB/TrEMBL

A0A8L2R003, A6J468

Conserved Domains (1) summary

cd01820
Location:8 → 217

PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...
XM_063266074.1 → XP_063122144.1 platelet-activating factor acetylhydrolase IB subunit alpha2 isoform X1

UniProtKB/Swiss-Prot

O35264

UniProtKB/TrEMBL

A0A8L2R003, A6J468