psmc5 proteasome 26S subunit, ATPase 5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: psmc5provided by ZNC
Official Full Name: proteasome 26S subunit, ATPase 5provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6547
See related: Ensembl:ENSDARG00000015315 AllianceGenome:ZFIN:ZDB-GENE-030131-6547
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:92464; wu:fa14g03; wu:fb23a11
Summary: Predicted to enable general transcription initiation factor binding activity; proteasome-activating activity; and thyrotropin-releasing hormone receptor binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within proteolysis. Predicted to be located in cytoplasm and nucleus. Predicted to be part of proteasome regulatory particle, base subcomplex. Orthologous to human PSMC5 (proteasome 26S subunit, ATPase 5). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (10163645..10175487)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (10125802..10137644)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AA606025 (e-PCR)
- UniSTS:206870

fb23a11 (e-PCR)
- UniSTS:188970

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables general transcription initiation factor binding	ISS Inferred from Sequence or Structural Similarity more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables proteasome-activating activity	IBA Inferred from Biological aspect of Ancestor more info
enables thyrotropin-releasing hormone receptor binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of proteasome complex	IEA Inferred from Electronic Annotation more info
part_of proteasome complex	ISS Inferred from Sequence or Structural Similarity more info
part_of proteasome regulatory particle, base subcomplex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 26S proteasome regulatory subunit 8

Names: proteasome (prosome, macropain) 26S subunit, ATPase, 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003740.1 → NP_001003740.1 26S proteasome regulatory subunit 8

See identical proteins and their annotated locations for NP_001003740.1

Status: PROVISIONAL

Source sequence(s)

BC078375

UniProtKB/TrEMBL

B2GTC2, Q6AZC1

Related

ENSDARP00000096969.4, ENSDART00000106191.6

Conserved Domains (3) summary

COG1222
Location:4 → 404

RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]

pfam00004
Location:186 → 318

AAA; ATPase family associated with various cellular activities (AAA)

pfam13191
Location:153 → 206

AAA_16; AAA ATPase domain