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    TRIB2 tribbles pseudokinase 2 [ Canis lupus familiaris (dog) ]

    Gene ID: 403884, updated on 17-Aug-2024

    Summary

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    Official Symbol
    TRIB2provided by VGNC
    Official Full Name
    tribbles pseudokinase 2provided by VGNC
    Primary source
    VGNC:VGNC:47801
    See related
    Ensembl:ENSCAFG00845029138
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    C5FW
    Orthologs
    human mouse all
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    Genomic context

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    See TRIB2 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 17 NC_051821.1 (9331314..9357639)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 17 NC_006599.4 (9159625..9182294)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 17 NC_049238.1 (9240169..9263855)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 17 NC_049277.1 (9221427..9244277)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 17 NC_049758.1 (9220767..9243473)

    Chromosome 17 - NC_051821.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119869806 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC106559881 Neighboring gene uncharacterized LOC106559882

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of novel genes modulated in the thyroid of dogs treated with methimazole and propylthiouracil. Wilkin F, et al. J Biol Chem, 1996 Nov 8. PMID 8910471
    2. Characterization of a phosphoprotein whose mRNA is regulated by the mitogenic pathways in dog thyroid cells. Wilkin F, et al. Eur J Biochem, 1997 Sep 15. PMID 9342215
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables mitogen-activated protein kinase kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tribbles homolog 2
    Names
    TRB-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003218.1 → NP_001003218.1  tribbles homolog 2

      See identical proteins and their annotated locations for NP_001003218.1

      Status: PROVISIONAL

      Source sequence(s)
      X99144
      UniProtKB/Swiss-Prot
      Q28283
      UniProtKB/TrEMBL
      A0A8C0LRC2
      Conserved Domains (1) summary
      cd14022
      Location:67 → 308
      PK_TRB2; Pseudokinase domain of Tribbles Homolog 2

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051821.1 Reference ROS_Cfam_1.0

      Range
      9331314..9357639
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038690438.1 → XP_038546366.1  tribbles homolog 2 isoform X1

      UniProtKB/Swiss-Prot
      Q28283
      UniProtKB/TrEMBL
      A0A8C0LRC2
      Related
      ENSCAFP00845040463.1, ENSCAFT00845051570.1
      Conserved Domains (1) summary
      cd14022
      Location:67 → 308
      PK_TRB2; Pseudokinase domain of Tribbles Homolog 2

    2. XM_038690437.1 → XP_038546365.1  tribbles homolog 2 isoform X1

      UniProtKB/Swiss-Prot
      Q28283
      UniProtKB/TrEMBL
      A0A8C0LRC2
      Conserved Domains (1) summary
      cd14022
      Location:67 → 308
      PK_TRB2; Pseudokinase domain of Tribbles Homolog 2

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049277.1 Alternate UMICH_Zoey_3.1

      Range
      9221427..9244277
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049758.1 Alternate UNSW_CanFamBas_1.0

      Range
      9220767..9243473
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049238.1 Alternate UU_Cfam_GSD_1.0

      Range
      9240169..9263855
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006599.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      9159625..9182294
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q28283.1 GenPept UniProtKB/Swiss-Prot:Q28283

    Gene LinkOut

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