sox19a SRY-box transcription factor 19a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sox19aprovided by ZNC
Official Full Name: SRY-box transcription factor 19aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-102
See related: Ensembl:ENSDARG00000010770 AllianceGenome:ZFIN:ZDB-GENE-980526-102
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb799; sox19; fc66c01; wu:fc66c01
Summary: Contributes to DNA-binding transcription factor activity. Acts upstream of or within positive regulation of DNA-binding transcription factor activity. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including blastomere; central nervous system; neural rod; presumptive diencephalon; and presumptive structure. Orthologous to human SOX15 (SRY-box transcription factor 15). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (24199180..24201444, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (23695380..23697644, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Significant increases in expression of sox 19a (up to 25-fold) were observed during warming in embryos that had been chilled for 30 min.
Title: Effect of chilling on sox2, sox3 and sox19a gene expression in zebrafish (Danio rerio) embryos.
Knockdown of the four B1 sox genes sox2/3/19a/19b resulted in severe developmental abnormalities.
Title: B1 SOX coordinate cell specification with patterning and morphogenesis in the early zebrafish embryo.

Submit: New GeneRIF Correction

General gene information

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Markers

fc26g02.y1 (e-PCR)
- UniSTS:193325

sox19 (e-PCR), detects polymorphism
- UniSTS:187036

sox19 (e-PCR), detects polymorphism
- UniSTS:238282

fc66c01.x1 (e-PCR)
- UniSTS:203989

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
contributes_to DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: transcription factor Sox-19a

Names: SRY (sex determining region Y)-box 19a; SRY-box containing gene 19a; transcription factor SOX19A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130908.2 → NP_570983.2 transcription factor Sox-19a

See identical proteins and their annotated locations for NP_570983.2

Status: VALIDATED

Source sequence(s)

CT607388, EH578674, EH609174

UniProtKB/Swiss-Prot

A2BEN6, P47792, Q6DC63

Related

ENSDARP00000100683.3, ENSDART00000114113.4

Conserved Domains (2) summary

cd01388
Location:52 → 123

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

pfam12336
Location:122 → 187

SOXp; SOX transcription factor