preb prolactin regulatory element binding [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: prebprovided by ZNC
Official Full Name: prolactin regulatory element bindingprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040718-385
See related: Ensembl:ENSDARG00000101602 AllianceGenome:ZFIN:ZDB-GENE-040718-385
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sb:cb385; zgc:92203; wu:fj59h11
Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and regulation of COPII vesicle coating. Predicted to act upstream of or within protein transport. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including axis; nervous system; notochord; polster; and solid lens vesicle. Orthologous to human PREB (prolactin regulatory element binding). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (2565497..2580408)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (2327831..2342742)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of COPII vesicle coating	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: guanine nucleotide-exchange factor SEC12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002638.1 → NP_001002638.1 guanine nucleotide-exchange factor SEC12

See identical proteins and their annotated locations for NP_001002638.1

Status: PROVISIONAL

Source sequence(s)

BC075936

UniProtKB/TrEMBL

A0A0R4IUH2, A8WG51, Q6DHN1

Related

ENSDARP00000137671.1, ENSDART00000171378.2

Conserved Domains (3) summary

COG2319
Location:169 → 378

WD40; WD40 repeat [General function prediction only]

sd00039
Location:165 → 201

7WD40; WD40 repeat [structural motif]

cl02567
Location:164 → 237

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...