gnb3a guanine nucleotide binding protein (G protein), beta polypeptide 3a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gnb3aprovided by ZNC
Official Full Name: guanine nucleotide binding protein (G protein), beta polypeptide 3aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040718-134
See related: Ensembl:ENSDARG00000004358 AllianceGenome:ZFIN:ZDB-GENE-040718-134
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: gnb3l; zgc:92641
Summary: Predicted to enable signaling receptor complex adaptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. Is expressed in nervous system. Human ortholog(s) of this gene implicated in artery disease (multiple); congenital stationary night blindness 1H; depressive disorder; familial hyperlipidemia; and type 2 diabetes mellitus. Orthologous to human GNB3 (G protein subunit beta 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (12022550..12049762)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (12131648..12158860)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables signaling receptor complex adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3a

Names: guanine nucleotide binding protein (G protein), beta polypeptide 3, like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002437.1 → NP_001002437.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3a

See identical proteins and their annotated locations for NP_001002437.1

Status: PROVISIONAL

Source sequence(s)

BC076127

UniProtKB/TrEMBL

F6PBP8, Q1MT88, Q6DH55

Related

ENSDARP00000017443.6, ENSDART00000012673.7

Conserved Domains (2) summary

cd00200
Location:48 → 340

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:58 → 95

7WD40; WD40 repeat [structural motif]