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    Nulp1 Nuclear localized protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38897, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nulp1provided by FlyBase
    Official Full Name
    Nuclear localized protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0027549
    Locus tag
    Dmel_CG7927
    See related
    AllianceGenome:FB:FBgn0027549
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0172774.138; BcDNA:GH11023; CG7927; Dmel\CG7927; dNulp1; TCF25
    Summary
    Predicted to enable DNA-binding transcription factor activity. Involved in positive regulation of canonical Wnt signaling pathway. Predicted to be located in nucleus. Predicted to be part of RQC complex. Is expressed in adult head and organism. Orthologous to human TCF25 (transcription factor 25). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nulp1 in Genome Data Viewer
    Location:
    66B6-66B6; 3-22 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8110368..8113406)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8103468..8106506)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Sterile alpha and Armadillo motif Neighboring gene uncharacterized protein Neighboring gene mir-2501 stem loop Neighboring gene farinelli Neighboring gene Actin-related protein 3 Neighboring gene moleskin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The bHLH Protein Nulp1 is Essential for Femur Development Via Acting as a Cofactor in Wnt Signaling in Drosophila. Zeng Q, et al. Curr Mol Med, 2018 Mar 9. PMID 29437009, Free PMC Article
    2. MicroRNA biogenesis via splicing and exosome-mediated trimming in Drosophila. Flynt AS, et al. Mol Cell, 2010 Jun 25. PMID 20620959, Free PMC Article
    3. Computational and experimental identification of mirtrons in Drosophila melanogaster and Caenorhabditis elegans. Chung WJ, et al. Genome Res, 2011 Feb. PMID 21177960, Free PMC Article
    4. The Extracellular and Cytoplasmic Domains of Syndecan Cooperate Postsynaptically to Promote Synapse Growth at the Drosophila Neuromuscular Junction. Nguyen MU, et al. PLoS One, 2016. PMID 26987116, Free PMC Article
    5. ZNF598 co-translationally titrates poly(GR) protein implicated in the pathogenesis of C9ORF72-associated ALS/FTD. Park J, et al. Nucleic Acids Res, 2021 Nov 8. PMID 34551427, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RQC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    nuclear localized protein 1
    Names
    CG7927-PA
    CG7927-PB
    CG7927-PC
    Nulp1-PA
    Nulp1-PB
    Nulp1-PC
    nuclear localized protein-1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8110368..8113406
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274629.1 → NP_001261558.1  nuclear localized protein 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261558.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VSD4, Q9Y109
      Conserved Domains (1) summary
      pfam04910
      Location:236 → 567
      Tcf25; Transcriptional repressor TCF25

    2. NM_001274628.1 → NP_001261557.1  nuclear localized protein 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261557.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PBV6
      Conserved Domains (1) summary
      pfam04910
      Location:236 → 567
      Tcf25; Transcriptional repressor TCF25

    3. NM_139917.3 → NP_648174.3  nuclear localized protein 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648174.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VSD4, Q9Y109
      Related
      FBpp0076407
      Conserved Domains (1) summary
      pfam04910
      Location:236 → 567
      Tcf25; Transcriptional repressor TCF25
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PBV6 M9PBV6
    Q9Y109 Q9Y109

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