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    MP1 Melanization Protease 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40541, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MP1provided by FlyBase
    Official Full Name
    Melanization Protease 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0027930
    Locus tag
    Dmel_CG1102
    See related
    AllianceGenome:FB:FBgn0027930
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:GH02921; CG1102; cSP25; Dmel\CG1102; proPO-AE; SP25
    Summary
    Enables serine-type endopeptidase activity. Involved in Toll receptor ligand protein activation cascade and melanization defense response. Predicted to be active in extracellular space. Is expressed in embryonic dorsal epidermis and embryonic/larval fat body. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See MP1 in Genome Data Viewer
    Location:
    82A3-82A3; 3-47.1 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4307908..4309835)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (133630..135557)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene complexin Neighboring gene Neprilysin-like 11 Neighboring gene mir-929 stem loop Neighboring gene antisense RNA:CR46140 Neighboring gene Vacuolar protein sorting 24 Neighboring gene Suv3 helicase Neighboring gene Synaptotagmin 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A complexin fusion clamp regulates spontaneous neurotransmitter release and synaptic growth. Huntwork S, et al. Nat Neurosci, 2007 Oct. PMID 17873870
    2. Drosophila PTPMT1 Has a Function in Tracheal Air Filling. Papakyrikos AM, et al. iScience, 2020 Jul 24. PMID 32629421, Free PMC Article
    3. Spätzle-Processing Enzyme-independent Activation of the Toll Pathway in Drosophila Innate Immunity. Yamamoto-Hino M, et al. Cell Struct Funct, 2016 May 7. PMID 26843333
    4. Two proteases defining a melanization cascade in the immune system of Drosophila. Tang H, et al. J Biol Chem, 2006 Sep 22. PMID 16861233
    5. In Drosophila Hemolymph, Serine Proteases Are the Major Gelatinases and Caseinases. Gatti JL, et al. Insects, 2024 Mar 28. PMID 38667364, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables serine hydrolase activity HDA PubMed 
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Toll receptor ligand protein activation cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in melanization defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in response to fungus HEP PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    melanization protease 1
    Names
    CG1102-PA
    CG1102-PC
    CG1102-PE
    MP1-PA
    MP1-PC
    MP1-PE
    NP_001138002.1
    NP_001303421.1
    NP_649450.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      4307908..4309835
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144530.2 → NP_001138002.1  melanization protease 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138002.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A126GUP6
      Conserved Domains (3) summary
      smart00020
      Location:136 → 393
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:137 → 396
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam12032
      Location:29 → 90
      CLIP; Regulatory CLIP domain of proteinases

    2. NM_001316492.1 → NP_001303421.1  melanization protease 1, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A126GUP6, B7Z0T0, E8NHA1, Q9Y157
      Conserved Domains (3) summary
      smart00020
      Location:137 → 394
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:138 → 397
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam12032
      Location:29 → 91
      CLIP; Regulatory CLIP domain of proteinases

    3. NM_141193.4 → NP_649450.3  melanization protease 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649450.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A126GUP6
      Related
      FBpp0078543
      Conserved Domains (3) summary
      smart00020
      Location:127 → 384
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:128 → 387
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam12032
      Location:29 → 81
      CLIP; Regulatory CLIP domain of proteinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A126GUP6.1 A0A126GUP6

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