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    Rnf144a ring finger protein 144A [ Mus musculus (house mouse) ]

    Gene ID: 108089, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rnf144aprovided by MGI
    Official Full Name
    ring finger protein 144Aprovided by MGI
    Primary source
    MGI:MGI:1344401
    See related
    Ensembl:ENSMUSG00000020642 AllianceGenome:MGI:1344401
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UIP4; Rnf144; Ubce7ip4
    Summary
    Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in pattern recognition receptor signaling pathway; protein K6-linked ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of ubiquitin ligase complex. Predicted to be active in Golgi apparatus and endoplasmic reticulum membrane. Orthologous to human RNF144A (ring finger protein 144A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in lung adult (RPKM 29.8), limb E14.5 (RPKM 11.1) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rnf144a in Genome Data Viewer
    Location:
    12 A2; 12 9.69 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (26356796..26465296, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (26306794..26415319, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 29687 Neighboring gene STARR-seq mESC enhancer starr_31786 Neighboring gene RIKEN cDNA 4930480M12 gene Neighboring gene predicted gene, 29968 Neighboring gene RIKEN cDNA 4930549C15 gene Neighboring gene STARR-seq mESC enhancer starr_31787 Neighboring gene microRNA 6538 Neighboring gene radical S-adenosyl methionine domain containing 2 Neighboring gene cytidine/uridine monophosphate kinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RNF144A promotes antiviral responses by modulating STING ubiquitination. Yang B, et al. EMBO Rep, 2023 Dec 6. PMID 37955227, Free PMC Article
    2. RNF144A deficiency promotes PD-L1 protein stabilization and carcinogen-induced bladder tumorigenesis. Ho SR, et al. Cancer Lett, 2021 Nov 1. PMID 34400221, Free PMC Article
    3. RNF144A sustains EGFR signaling to promote EGF-dependent cell proliferation. Ho SR, et al. J Biol Chem, 2018 Oct 19. PMID 30171075, Free PMC Article
    4. RNF144A, an E3 ubiquitin ligase for DNA-PKcs, promotes apoptosis during DNA damage. Ho SR, et al. Proc Natl Acad Sci U S A, 2014 Jul 1. PMID 24979766, Free PMC Article
    5. A family of structurally related RING finger proteins interacts specifically with the ubiquitin-conjugating enzyme UbcM4. Martinez-Noel G, et al. FEBS Lett, 1999 Jul 9. PMID 10431818

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNF144A promotes antiviral responses by modulating STING ubiquitination.
      Title: RNF144A promotes antiviral responses by modulating STING ubiquitination.
    2. RNF144A deficiency promotes PD-L1 protein stabilization and carcinogen-induced bladder tumorigenesis.
      Title: RNF144A deficiency promotes PD-L1 protein stabilization and carcinogen-induced bladder tumorigenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in pattern recognition receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pattern recognition receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K6-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein K6-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF144A
    Names
    probable E3 ubiquitin-protein ligase RNF144A
    ubcM4-interacting protein 4
    ubiquitin-conjugating enzyme 7-interacting protein 4
    NP_001075446.1
    NP_001400409.1
    NP_001400410.1
    NP_001400411.1
    NP_001400412.1
    NP_001400413.1
    NP_001400414.1
    NP_001400415.1
    NP_542130.1
    XP_006515007.1
    XP_030102368.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081977.3 → NP_001075446.1  E3 ubiquitin-protein ligase RNF144A isoform 1

      See identical proteins and their annotated locations for NP_001075446.1

      Status: VALIDATED

      Source sequence(s)
      AC156798
      Consensus CDS
      CCDS36425.1
      UniProtKB/Swiss-Prot
      Q3UZZ0, Q6A0B4, Q925F3
      Related
      ENSMUSP00000020971.7, ENSMUST00000020971.14
      Conserved Domains (3) summary
      smart00647
      Location:91 → 156
      IBR; In Between Ring fingers
      cd16777
      Location:19 → 72
      mRING-HC-C4C4_RBR_RNF144A; Modified RING finger, HC subclass (C4C4-type), found in RING finger protein 144A (RNF144A)
      pfam01485
      Location:179 → 216
      IBR; IBR domain, a half RING-finger domain

    2. NM_001413480.1 → NP_001400409.1  E3 ubiquitin-protein ligase RNF144A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC156798
      UniProtKB/Swiss-Prot
      Q3UZZ0, Q6A0B4, Q925F3

    3. NM_001413481.1 → NP_001400410.1  E3 ubiquitin-protein ligase RNF144A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC156798
      UniProtKB/Swiss-Prot
      Q3UZZ0, Q6A0B4, Q925F3

    4. NM_001413482.1 → NP_001400411.1  E3 ubiquitin-protein ligase RNF144A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC156798
      UniProtKB/Swiss-Prot
      Q3UZZ0, Q6A0B4, Q925F3

    5. NM_001413483.1 → NP_001400412.1  E3 ubiquitin-protein ligase RNF144A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC156798
      UniProtKB/Swiss-Prot
      Q3UZZ0, Q6A0B4, Q925F3

    6. NM_001413484.1 → NP_001400413.1  E3 ubiquitin-protein ligase RNF144A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC156798
      UniProtKB/Swiss-Prot
      Q3UZZ0, Q6A0B4, Q925F3

    7. NM_001413485.1 → NP_001400414.1  E3 ubiquitin-protein ligase RNF144A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC156798
      UniProtKB/Swiss-Prot
      Q3UZZ0, Q6A0B4, Q925F3

    8. NM_001413486.1 → NP_001400415.1  E3 ubiquitin-protein ligase RNF144A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC156798

    9. NM_080563.5 → NP_542130.1  E3 ubiquitin-protein ligase RNF144A isoform 1

      See identical proteins and their annotated locations for NP_542130.1

      Status: VALIDATED

      Source sequence(s)
      AC156798
      Consensus CDS
      CCDS36425.1
      UniProtKB/Swiss-Prot
      Q3UZZ0, Q6A0B4, Q925F3
      Related
      ENSMUSP00000056073.5, ENSMUST00000062149.6
      Conserved Domains (3) summary
      smart00647
      Location:91 → 156
      IBR; In Between Ring fingers
      cd16777
      Location:19 → 72
      mRING-HC-C4C4_RBR_RNF144A; Modified RING finger, HC subclass (C4C4-type), found in RING finger protein 144A (RNF144A)
      pfam01485
      Location:179 → 216
      IBR; IBR domain, a half RING-finger domain

    RNA

    1. NR_182154.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC156798

    2. NR_182155.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC156798

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      26356796..26465296 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514944.5 → XP_006515007.1  E3 ubiquitin-protein ligase RNF144A isoform X1

      Conserved Domains (3) summary
      smart00647
      Location:112 → 177
      IBR; In Between Ring fingers
      cd16777
      Location:40 → 93
      mRING-HC-C4C4_RBR_RNF144A; Modified RING finger, HC subclass (C4C4-type), found in RING finger protein 144A (RNF144A)
      pfam01485
      Location:200 → 237
      IBR; IBR domain, a half RING-finger domain

    2. XM_030246508.1 → XP_030102368.1  E3 ubiquitin-protein ligase RNF144A isoform X2

      UniProtKB/Swiss-Prot
      Q3UZZ0, Q6A0B4, Q925F3
      Conserved Domains (3) summary
      smart00647
      Location:91 → 156
      IBR; In Between Ring fingers
      cd16777
      Location:19 → 72
      mRING-HC-C4C4_RBR_RNF144A; Modified RING finger, HC subclass (C4C4-type), found in RING finger protein 144A (RNF144A)
      pfam01485
      Location:179 → 216
      IBR; IBR domain, a half RING-finger domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q925F3.1 GenPept UniProtKB/Swiss-Prot:Q925F3

    Gene LinkOut

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