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    dpm1 dolichyl-phosphate mannosyltransferase subunit 1, catalytic [ Danio rerio (zebrafish) ]

    Gene ID: 445202, updated on 9-Dec-2024

    Summary

    Official Symbol
    dpm1provided by ZNC
    Official Full Name
    dolichyl-phosphate mannosyltransferase subunit 1, catalyticprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040801-115
    See related
    Ensembl:ENSDARG00000057011 AllianceGenome:ZFIN:ZDB-GENE-040801-115
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:101018
    Summary
    Predicted to enable dolichyl-phosphate beta-D-mannosyltransferase activity and dolichyl-phosphate-mannose-protein mannosyltransferase activity. Acts upstream of or within muscle structure development. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Is expressed in brain; cloaca; pronephric duct; solid lens vesicle; and vertical myoseptum. Used to study congenital disorder of glycosylation type I. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ie. Orthologous to human DPM1 (dolichyl-phosphate mannosyltransferase subunit 1, catalytic). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See dpm1 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (20513128..20517429)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (20586785..20591086)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 35 member C2 Neighboring gene collagen type XX alpha 1 chain Neighboring gene activity-dependent neuroprotector homeobox b Neighboring gene skin secretory protein xP2-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables dolichyl-phosphate beta-D-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables dolichyl-phosphate beta-D-mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables dolichyl-phosphate beta-D-mannosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables dolichyl-phosphate-mannose-protein mannosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in GPI anchor biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in dolichol-linked oligosaccharide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within muscle structure development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein O-linked mannosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein O-linked mannosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein mannosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    dolichol-phosphate mannosyltransferase subunit 1
    Names
    dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
    NP_001003596.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003596.1NP_001003596.1  dolichol-phosphate mannosyltransferase subunit 1

      See identical proteins and their annotated locations for NP_001003596.1

      Status: PROVISIONAL

      Source sequence(s)
      BC077113
      UniProtKB/TrEMBL
      A0A8M1N1P1, Q6DEJ9
      Related
      ENSDARP00000074043.2, ENSDART00000079591.3
      Conserved Domains (2) summary
      cd06442
      Location:19246
      DPM1_like; DPM1_like represents putative enzymes similar to eukaryotic DPM1
      PLN02726
      Location:8250
      PLN02726; dolichyl-phosphate beta-D-mannosyltransferase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      20513128..20517429
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395143.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      237335..241643
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)