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    SAMDC S-adenosylmethionine decarboxylase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821214, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SAMDC
    Official Full Name
    S-adenosylmethionine decarboxylase
    Primary source
    TAIR:AT3G02470
    Locus tag
    AT3G02470
    See related
    Araport:AT3G02470
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ADOMETDC; F16B3.10; F16B3_10; S-adenosylmethionine decarboxylase; S-ADENOSYLMETHIONINE DECARBOXYLASE
    Summary
    Encodes a S-adenosylmethionine decarboxylase involved in polyamine biosynthesis.
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    Genomic context

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    See SAMDC in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    5
    Sequence:
    Chromosome: 3; NC_003074.8 (508886..511561)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene cell division protein ftsH Neighboring gene Ypt/Rab-GAP domain of gyp1p superfamily protein Neighboring gene Late embryogenesis abundant protein (LEA) family protein Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Polyamine-responsive ribosomal arrest at the stop codon of an upstream open reading frame of the AdoMetDC1 gene triggers nonsense-mediated mRNA decay in Arabidopsis thaliana. Uchiyama-Kadokura N, et al. Plant Cell Physiol, 2014 Sep. PMID 24929422
    2. The diverse bacterial origins of the Arabidopsis polyamine biosynthetic pathway. Illingworth C, et al. FEBS Lett, 2003 Aug 14. PMID 12914918
    3. Identification of functionally important residues of Arabidopsis thaliana S-adenosylmethionine decarboxylase. Park SJ, et al. J Biochem, 1999 Dec. PMID 10578049
    4. Over-expression of WOX1 leads to defects in meristem development and polyamine homeostasis in Arabidopsis. Zhang Y, et al. J Integr Plant Biol, 2011 Jun. PMID 21658178
    5. BSCTV C2 attenuates the degradation of SAMDC1 to suppress DNA methylation-mediated gene silencing in Arabidopsis. Zhang Z, et al. Plant Cell, 2011 Jan. PMID 21245466, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AdoMetDC1 upstream open reading frame (uORF) peptide-mediated ribosomal arrest at the uORF stop codon induces nonsense-mediated mRNA decay (NMD).
      Title: Polyamine-responsive ribosomal arrest at the stop codon of an upstream open reading frame of the AdoMetDC1 gene triggers nonsense-mediated mRNA decay in Arabidopsis thaliana.
    2. BSCTV C2 inhibits 26S proteasome-mediated degradation of SAMDC1.
      Title: BSCTV C2 attenuates the degradation of SAMDC1 to suppress DNA methylation-mediated gene silencing in Arabidopsis.
    3. BUD2, encoding an S-adenosylmethionine decarboxylase, is required for Arabidopsis growth and development.
      Title: BUD2, encoding an S-adenosylmethionine decarboxylase, is required for Arabidopsis growth and development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Miscellaneous features

    • Loc: 509815-509952 AT3G02470.uORF1-1
    • Loc: 510048-510068 AT3G02470.uORF1-2
    NM_001084624.1
    NM_001161113.1
    NM_111114.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables adenosylmethionine decarboxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in plant organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within polyamine biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in spermidine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within viral genome replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    S-adenosylmethionine decarboxylase
    NP_001078093.1
    • S-adenosylmethionine decarboxylase (SAMDC); CONTAINS InterPro DOMAIN/s: S-adenosylmethionine decarboxylase, core (InterPro:IPR016067), S-adenosylmethionine decarboxylase (InterPro:IPR001985), S-adenosylmethionine decarboxylase, conserved site (InterPro:IPR018166), S-adenosylmethionine decarboxylase subgroup (InterPro:IPR018167); BEST Arabidopsis thaliana protein match is: Adenosylmethionine decarboxylase family protein (TAIR:AT5G15950.2); Has 1026 Blast hits to 1010 proteins in 271 species: Archae - 0; Bacteria - 57; Metazoa - 220; Fungi - 150; Plants - 531; Viruses - 0; Other Eukaryotes - 68 (source: NCBI BLink).
    NP_001154585.1
    • S-adenosylmethionine decarboxylase; CONTAINS InterPro DOMAIN/s: S-adenosylmethionine decarboxylase, core (InterPro:IPR016067), S-adenosylmethionine decarboxylase (InterPro:IPR001985), S-adenosylmethionine decarboxylase, conserved site (InterPro:IPR018166), S-adenosylmethionine decarboxylase subgroup (InterPro:IPR018167); BEST Arabidopsis thaliana protein match is: Adenosylmethionine decarboxylase family protein (TAIR:AT5G15950.2); Has 1026 Blast hits to 1010 proteins in 271 species: Archae - 0; Bacteria - 57; Metazoa - 220; Fungi - 150; Plants - 531; Viruses - 0; Other Eukaryotes - 68 (source: NCBI BLink).
    NP_186896.1
    • S-adenosylmethionine decarboxylase (SAMDC); CONTAINS InterPro DOMAIN/s: S-adenosylmethionine decarboxylase, core (InterPro:IPR016067), S-adenosylmethionine decarboxylase, conserved site (InterPro:IPR018166), S-adenosylmethionine decarboxylase (InterPro:IPR001985), S-adenosylmethionine decarboxylase subgroup (InterPro:IPR018167); BEST Arabidopsis thaliana protein match is: Adenosylmethionine decarboxylase family protein (TAIR:AT5G15950.2); Has 1026 Blast hits to 1010 proteins in 271 species: Archae - 0; Bacteria - 57; Metazoa - 220; Fungi - 150; Plants - 531; Viruses - 0; Other Eukaryotes - 68 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      508886..511561
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001161113.1 → NP_001154585.1  S-adenosylmethionine decarboxylase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001154585.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DFT1, Q96286, Q96531, Q9M893
      UniProtKB/TrEMBL
      A0A178VEW3, A0A5S9X8G2, Q940Q5
      Conserved Domains (1) summary
      PLN02524
      Location:1 → 358
      PLN02524; S-adenosylmethionine decarboxylase

    2. NM_001084624.1 → NP_001078093.1  S-adenosylmethionine decarboxylase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078093.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DFT1, Q96286, Q96531, Q9M893
      UniProtKB/TrEMBL
      A0A178VEW3, A0A5S9X8G2, Q940Q5
      Conserved Domains (1) summary
      PLN02524
      Location:1 → 358
      PLN02524; S-adenosylmethionine decarboxylase

    3. NM_111114.2 → NP_186896.1  S-adenosylmethionine decarboxylase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_186896.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DFT1, Q96286, Q96531, Q9M893
      UniProtKB/TrEMBL
      A0A178VEW3, A0A5S9X8G2, Q940Q5
      Conserved Domains (1) summary
      PLN02524
      Location:1 → 358
      PLN02524; S-adenosylmethionine decarboxylase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96286.2

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