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    HB-8 homeobox-leucine zipper protein ATHB-8 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829424, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HB-8
    Official Full Name
    homeobox-leucine zipper protein ATHB-8
    Primary source
    TAIR:AT4G32880
    Locus tag
    AT4G32880
    See related
    Araport:AT4G32880
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATHB-8; ATHB8; homeobox gene 8; T16I18.90; T16I18_90
    Summary
    member of homeodomain-leucine zipper family, acting as a differentiation-promoting transcription factor of the vascular meristems.
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    Genomic context

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    See HB-8 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    18
    Sequence:
    Chromosome: 4; NC_003075.7 (15863339..15868650, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Avr9/Cf-9 rapidly elicited protein Neighboring gene Polyketide cyclase/dehydrase and lipid transport superfamily protein Neighboring gene GATA transcription factor 9 Neighboring gene Peptidyl-tRNA hydrolase II (PTH2) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The expression of the Athb-8 homeobox gene is restricted to provascular cells in Arabidopsis thaliana. Baima S, et al. Development, 1995 Dec. PMID 8575317
    2. Simultaneous activation of SHR and ATHB8 expression defines switch to preprocambial cell state in Arabidopsis leaf development. Gardiner J, et al. Dev Dyn, 2011 Jan. PMID 21128301
    3. Auxin signal transduction in Arabidopsis vein formation. Donner TJ, et al. Plant Signal Behav, 2010 Jan. PMID 20592815, Free PMC Article
    4. Auxin signaling in Arabidopsis leaf vascular development. Mattsson J, et al. Plant Physiol, 2003 Mar. PMID 12644682, Free PMC Article
    5. The arabidopsis ATHB-8 HD-zip protein acts as a differentiation-promoting transcription factor of the vascular meristems. Baima S, et al. Plant Physiol, 2001 Jun. PMID 11402194, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Congruence between SHR and ATHB8 expression domains persists under conditions of manipulated vein patterning, suggesting that inception of expression of SHR and ATHB8 identifies transition to a preprocambial cell state that presages vein formation.
      Title: Simultaneous activation of SHR and ATHB8 expression defines switch to preprocambial cell state in Arabidopsis leaf development.
    2. Data show that the expression of 3 DOF genes DOF2.1 (At2g28510), DOF4.6 (At4g24060) and DOF5.3 (At5g60200) is activated at early vascular development stages overlapping onset of ATHB8 expression.
      Title: Expression of DOF genes identifies early stages of vascular development in Arabidopsis leaves.
    3. Here we discuss putative mechanisms by which wide domains of MP expression could activate ATHB8 transcription in single cell files.
      Title: Auxin signal transduction in Arabidopsis vein formation.
    4. Class III HD-Zip AND KANADI genes required for root development [ATHB8]
      Title: Roles for Class III HD-Zip and KANADI genes in Arabidopsis root development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_119441.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within meristem initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within primary shoot apical meristem specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within procambium histogenesis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to auxin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within xylem development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    homeobox-leucine zipper protein ATHB-8
    NP_195014.1
    • homeobox gene 8 (HB-8); CONTAINS InterPro DOMAIN/s: Basic-leucine zipper (bZIP) transcription factor (InterPro:IPR004827), Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), Lipid-binding START (InterPro:IPR002913), MEKHLA (InterPro:IPR013978), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein (TAIR:AT1G52150.1); Has 3304 Blast hits to 3224 proteins in 267 species: Archae - 0; Bacteria - 6; Metazoa - 860; Fungi - 101; Plants - 2302; Viruses - 0; Other Eukaryotes - 35 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      15863339..15868650 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119441.5 → NP_195014.1  homeobox-leucine zipper protein ATHB-8 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195014.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q39123
      UniProtKB/TrEMBL
      A0A178UUJ8, A0A5S9XYI2
      Conserved Domains (4) summary
      cd08875
      Location:154 → 369
      START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins
      cd14686
      Location:67 → 106
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      pfam00046
      Location:15 → 73
      Homeobox; Homeobox domain
      pfam08670
      Location:692 → 832
      MEKHLA; MEKHLA domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q39123.1

    Gene LinkOut

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